FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143802308> ?p ?o ?g. }

• W3143802308 endingPage "5848" @default.
• W3143802308 startingPage "5839" @default.
• W3143802308 abstract "The multiple-metal-nanoparticle tagging strategy has generally been applied to the multiplexed detection of multiple analytes of interest such as microRNAs (miRNAs). Herein, it was used for the first time to improve both the specificity and sensitivity of a novel mass spectroscopic platform for miRNA detection. The mass spectroscopic platform was developed through the integration of the ligation reaction, hybridization chain reaction amplification, multiple-metal-nanoparticle tagging, and inductively coupled plasma mass spectrometry. The high specificity resulted from the adoption of the ligation reaction is further enhanced by the multiple-metal-nanoparticle tagging strategy. The combination of hybridization chain reaction amplification and metal nanoparticle tagging endows the proposed platform with the feature of high sensitivity. The proposed mass spectrometric platform achieved quite satisfactory quantitative results for Let-7a in real-world cell line samples with accuracy comparable to that of the real-time quantitative reverse-transcriptase polymerase chain reaction method. Its limit of detection and limit of quantification for Let-7a were experimentally determined to be about 0.5 and 10 fM, respectively. Furthermore, due to the unique way of utilizing the multiple-metal-nanoparticle tagging strategy, the proposed platform can unambiguously discriminate between the target miRNA and nontarget ones with single-nucleotide polymorphisms based on their response patterns defined by the relative mass spectral intensities among the multiple tagged metal elements and can also provide location information of the mismatched bases. Its unique advantages over conventional miRNA detection methods make the proposed platform a promising and alternative tool in the fields of clinical diagnosis and biomedical research." @default.
• W3143802308 created "2021-04-13" @default.
• W3143802308 creator A5025152082 @default.
• W3143802308 creator A5039359827 @default.
• W3143802308 creator A5075028515 @default.
• W3143802308 creator A5081954851 @default.
• W3143802308 creator A5084902025 @default.
• W3143802308 date "2021-04-02" @default.
• W3143802308 modified "2023-09-24" @default.
• W3143802308 title "Highly Sensitive and Specific Mass Spectrometric Platform for miRNA Detection Based on the Multiple-Metal-Nanoparticle Tagging Strategy" @default.
• W3143802308 cites W144423133 @default.
• W3143802308 cites W1932713539 @default.
• W3143802308 cites W1975343993 @default.
• W3143802308 cites W2003847725 @default.
• W3143802308 cites W2047535851 @default.
• W3143802308 cites W2054048470 @default.
• W3143802308 cites W2078364654 @default.
• W3143802308 cites W2079198651 @default.
• W3143802308 cites W2090470897 @default.
• W3143802308 cites W2090741383 @default.
• W3143802308 cites W2105988030 @default.
• W3143802308 cites W2108417458 @default.
• W3143802308 cites W2109117297 @default.
• W3143802308 cites W2130823364 @default.
• W3143802308 cites W2238765953 @default.
• W3143802308 cites W2316594247 @default.
• W3143802308 cites W2323017817 @default.
• W3143802308 cites W2323680795 @default.
• W3143802308 cites W2324853962 @default.
• W3143802308 cites W2335415310 @default.
• W3143802308 cites W2339462174 @default.
• W3143802308 cites W2394854392 @default.
• W3143802308 cites W2501231042 @default.
• W3143802308 cites W2547357254 @default.
• W3143802308 cites W2553765446 @default.
• W3143802308 cites W2607421560 @default.
• W3143802308 cites W2735699461 @default.
• W3143802308 cites W2766527624 @default.
• W3143802308 cites W2769434759 @default.
• W3143802308 cites W2775390670 @default.
• W3143802308 cites W2780587193 @default.
• W3143802308 cites W2781495483 @default.
• W3143802308 cites W2785719984 @default.
• W3143802308 cites W2803150609 @default.
• W3143802308 cites W2805824699 @default.
• W3143802308 cites W2807273705 @default.
• W3143802308 cites W2821496710 @default.
• W3143802308 cites W2894495054 @default.
• W3143802308 cites W2898203005 @default.
• W3143802308 cites W2898319263 @default.
• W3143802308 cites W2906350950 @default.
• W3143802308 cites W2912829358 @default.
• W3143802308 cites W2948210038 @default.
• W3143802308 cites W2951736036 @default.
• W3143802308 cites W2954425519 @default.
• W3143802308 cites W2974271220 @default.
• W3143802308 cites W2980027492 @default.
• W3143802308 cites W2994893285 @default.
• W3143802308 cites W2997343598 @default.
• W3143802308 cites W2999435065 @default.
• W3143802308 cites W3033302765 @default.
• W3143802308 cites W3040556124 @default.
• W3143802308 cites W3045825743 @default.
• W3143802308 cites W3111795209 @default.
• W3143802308 cites W4256507586 @default.
• W3143802308 doi "https://doi.org/10.1021/acs.analchem.1c00065" @default.
• W3143802308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33797890" @default.
• W3143802308 hasPublicationYear "2021" @default.
• W3143802308 type Work @default.
• W3143802308 sameAs 3143802308 @default.
• W3143802308 citedByCount "18" @default.
• W3143802308 countsByYear W31438023082021 @default.
• W3143802308 countsByYear W31438023082022 @default.
• W3143802308 countsByYear W31438023082023 @default.
• W3143802308 crossrefType "journal-article" @default.
• W3143802308 hasAuthorship W3143802308A5025152082 @default.
• W3143802308 hasAuthorship W3143802308A5039359827 @default.
• W3143802308 hasAuthorship W3143802308A5075028515 @default.
• W3143802308 hasAuthorship W3143802308A5081954851 @default.
• W3143802308 hasAuthorship W3143802308A5084902025 @default.
• W3143802308 hasConcept C104317684 @default.
• W3143802308 hasConcept C145059251 @default.
• W3143802308 hasConcept C155672457 @default.
• W3143802308 hasConcept C162356407 @default.
• W3143802308 hasConcept C171250308 @default.
• W3143802308 hasConcept C185592680 @default.
• W3143802308 hasConcept C192562407 @default.
• W3143802308 hasConcept C21951064 @default.
• W3143802308 hasConcept C43617362 @default.
• W3143802308 hasConcept C55493867 @default.
• W3143802308 hasConceptScore W3143802308C104317684 @default.
• W3143802308 hasConceptScore W3143802308C145059251 @default.
• W3143802308 hasConceptScore W3143802308C155672457 @default.
• W3143802308 hasConceptScore W3143802308C162356407 @default.
• W3143802308 hasConceptScore W3143802308C171250308 @default.
• W3143802308 hasConceptScore W3143802308C185592680 @default.
• W3143802308 hasConceptScore W3143802308C192562407 @default.
• W3143802308 hasConceptScore W3143802308C21951064 @default.

• next