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• W3143813638 abstract "HomeCirculationVol. 137, No. 3Letter by Jin-shan and Xue-bin Regarding Article, “Prospective Study of Adenosine on Atrioventricular Nodal Conduction in Pediatric and Young Adult Patients After Heart Transplantation” Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBLetter by Jin-shan and Xue-bin Regarding Article, “Prospective Study of Adenosine on Atrioventricular Nodal Conduction in Pediatric and Young Adult Patients After Heart Transplantation” He Jin-shan, MD and Li Xue-bin, MD He Jin-shanHe Jin-shan Department of Cardiology, Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People’s Hospital, Beijing, China. Search for more papers by this author and Li Xue-binLi Xue-bin Department of Cardiology, Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People’s Hospital, Beijing, China. Search for more papers by this author Originally published16 Jan 2018https://doi.org/10.1161/CIRCULATIONAHA.117.030854Circulation. 2018;137:314To the Editor:We read with great interest the article by Flyer and colleagues1 about the study of adenosine on atrioventricular nodal conduction in pediatric and young adult patients after heart transplantation, which establishes both safe and effective starting doses (25 μg/kg; 1.5 mg for patients ≥60 kg), in addition to a stepwise therapy escalation plan that avoids prolonged bradycardia and has a great effect on the use of adenosine in patients after heart transplantation with supraventricular tachycardia. We have a suggestion about this study. After heart transplantation, atrioventricular node is denervated; however, during the supraventricular tachycardia episode, activation of sympathetic activity through the hormonal system still occurs. This action may change the electrophysiological properties of the atrioventricular node. The Flyer et al study1 is conducted in normal sinus rhythm instead of supraventricular tachycardia. The results cannot represent safe and effective doses for terminating supraventricular tachycardia completely. More research needs to be done about the treating effect of adenosine on supraventricular tachycardia in this special group of patients to find the real safe and effective doses.He Jin-shan, MDLi Xue-bin, MDDisclosuresNone.FootnotesCirculation is available at http://circ.ahajournals.org.References1. Flyer JN, Zuckerman WA, Richmond ME, Anderson BR, Mendelsberg TG, McAllister JM, Liberman L, Addonizio LJ, Silver ES. Prospective study of adenosine on atrioventricular nodal conduction in pediatric and young adult patients after heart transplantation.Circulation. 2017; 135:2485–2493. doi: 10.1161/CIRCULATIONAHA.117.028087.LinkGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails January 16, 2018Vol 137, Issue 3 Advertisement Article InformationMetrics © 2018 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.117.030854PMID: 29335294 Originally publishedJanuary 16, 2018 PDF download Advertisement" @default.
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