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- W3143867892 abstract "Abstract The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood. Here we combine single-molecule spectroscopy with all-atom simulations to uncover the molecular details that contribute to N protein function. N protein contains three dynamic disordered regions that house putative transiently-helical binding motifs. The two folded domains interact minimally such that full-length N protein is a flexible and multivalent RNA-binding protein. N protein also undergoes liquid-liquid phase separation when mixed with RNA, and polymer theory predicts that the same multivalent interactions that drive phase separation also engender RNA compaction. We offer a simple symmetry-breaking model that provides a plausible route through which single-genome condensation preferentially occurs over phase separation, suggesting that phase separation offers a convenient macroscopic readout of a key nanoscopic interaction." @default.
- W3143867892 created "2021-04-13" @default.
- W3143867892 creator A5005678901 @default.
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- W3143867892 creator A5077603599 @default.
- W3143867892 date "2021-03-29" @default.
- W3143867892 modified "2023-10-11" @default.
- W3143867892 title "The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA" @default.
- W3143867892 cites W1031578623 @default.
- W3143867892 cites W1825536795 @default.
- W3143867892 cites W1854281301 @default.
- W3143867892 cites W1888838956 @default.
- W3143867892 cites W1898130445 @default.
- W3143867892 cites W1952608303 @default.
- W3143867892 cites W1963601673 @default.
- W3143867892 cites W1970022221 @default.
- W3143867892 cites W1972715299 @default.
- W3143867892 cites W1974479059 @default.
- W3143867892 cites W197496138 @default.
- W3143867892 cites W1978689710 @default.
- W3143867892 cites W1983758346 @default.
- W3143867892 cites W1989969147 @default.
- W3143867892 cites W1990649962 @default.
- W3143867892 cites W1994840640 @default.
- W3143867892 cites W2002900623 @default.
- W3143867892 cites W2004809395 @default.
- W3143867892 cites W2006322736 @default.
- W3143867892 cites W2016143380 @default.
- W3143867892 cites W2018779610 @default.
- W3143867892 cites W2022377170 @default.
- W3143867892 cites W2022938456 @default.
- W3143867892 cites W2023487073 @default.
- W3143867892 cites W2026516400 @default.
- W3143867892 cites W2028814809 @default.
- W3143867892 cites W2029536746 @default.
- W3143867892 cites W2029582401 @default.
- W3143867892 cites W2031215694 @default.
- W3143867892 cites W2035443421 @default.
- W3143867892 cites W2040092952 @default.
- W3143867892 cites W2041239233 @default.
- W3143867892 cites W2042024446 @default.
- W3143867892 cites W2051633053 @default.
- W3143867892 cites W2053562742 @default.
- W3143867892 cites W2054352933 @default.
- W3143867892 cites W2055582900 @default.
- W3143867892 cites W2055854433 @default.
- W3143867892 cites W2058517217 @default.
- W3143867892 cites W2059530064 @default.
- W3143867892 cites W2063237839 @default.
- W3143867892 cites W2068129612 @default.
- W3143867892 cites W2082256695 @default.
- W3143867892 cites W2082810430 @default.
- W3143867892 cites W2083091243 @default.
- W3143867892 cites W2085978470 @default.
- W3143867892 cites W2087168349 @default.
- W3143867892 cites W2094875270 @default.
- W3143867892 cites W2099790244 @default.
- W3143867892 cites W2099839322 @default.
- W3143867892 cites W2104414253 @default.
- W3143867892 cites W2106107191 @default.
- W3143867892 cites W2108216588 @default.
- W3143867892 cites W2109026766 @default.
- W3143867892 cites W2109856842 @default.
- W3143867892 cites W2134446020 @default.
- W3143867892 cites W2140471782 @default.
- W3143867892 cites W2140899968 @default.
- W3143867892 cites W2148723336 @default.
- W3143867892 cites W2152382499 @default.
- W3143867892 cites W2163595857 @default.
- W3143867892 cites W2164319770 @default.
- W3143867892 cites W2208231611 @default.
- W3143867892 cites W2345839951 @default.
- W3143867892 cites W2417954325 @default.
- W3143867892 cites W2418534521 @default.
- W3143867892 cites W2510171377 @default.
- W3143867892 cites W2515213957 @default.
- W3143867892 cites W2516164831 @default.
- W3143867892 cites W2518447755 @default.
- W3143867892 cites W2547162692 @default.
- W3143867892 cites W2560537404 @default.
- W3143867892 cites W2589839191 @default.
- W3143867892 cites W2590568317 @default.
- W3143867892 cites W2591203500 @default.
- W3143867892 cites W2619239407 @default.
- W3143867892 cites W2731724500 @default.
- W3143867892 cites W2734982535 @default.
- W3143867892 cites W2735801899 @default.
- W3143867892 cites W2736387338 @default.
- W3143867892 cites W2756821926 @default.