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- W3143876605 abstract "Objective To study the medicine dynamics, distribution in tissue and abdominal cavity fluid concentration of 5-FU after giving intraperitoneal by using a gelatin carrier to be made 5-FU slowing-release microballoons. Methods 5-FU slowing-release microballoons medicine release speed, tissue distributing and the concentration in abdominal cavity fluid were measured by high performance liquid chromatography. Results 5-FU wrapped by gelatin were slowly released. The concentration in abdominal cavity fluid was obviously higher than that in tissue or in blood. Using established standard curve line, it was proved that in body area under curve (AUC) of 5-FU slowing-release microballoons group was obviously higher than that of simple 5-FU injection group, analyzed by 3p97 pharmacokinetic software management. Conclusion 5-FU enwrapped by gelatin can retain an effective anticancer activity concentration in abdominal cavity 7 days after giving intraperitoneal and it is distributed mostly in abdominal cavity." @default.
- W3143876605 created "2021-04-13" @default.
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- W3143876605 date "2008-01-01" @default.
- W3143876605 modified "2023-09-23" @default.
- W3143876605 title "Animal Experiment of 5-FU Slowing-Release Microballoons Given Intraperitoneal" @default.
- W3143876605 hasPublicationYear "2008" @default.
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