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- W3143906166 abstract "Publisher Summary This chapter describes the classification and structure of protein tyrosine kinases (PTKs), their mode of action, their cellular targets, and the processes in which they are involved. A vast amount of research has been carried out to try to identify the role of PTKs in the general functioning and development of normal mammalian cells, and in the uncontrolled proliferation of malignant cells. Although this work is primarily concerned with PTK inhibitors, it is important to understand the structure and function of the target enzymes in order to appreciate the rationale behind the search for inhibitors. The protein tyrosine kinase family of enzymes can be broadly classified into two groups; receptor protein tyrosine kinases and non-receptor protein tyrosine kinases, depending upon whether or not they possess extracellular ligand-binding domains. The catalytic activity of the receptor PTKs is initiated by the binding of the appropriate ligand to the extracellular domain. This leads to receptor oligomerization , which enables interaction between the adjacent cytoplasmic domains." @default.
- W3143906166 created "2021-04-13" @default.
- W3143906166 creator A5021150000 @default.
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- W3143906166 date "1996-01-01" @default.
- W3143906166 modified "2023-09-24" @default.
- W3143906166 title "6 Protein Tyrosine Kinase Inhibitors" @default.
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