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- W3143921111 abstract "Catalpol， iridoid glycoside，被显示了由 rescuing mitochondrial 功能，而是详细机制遗体施加血糖过低的效果不清楚还。在这研究，在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖， triglyceride，和胆固醇层次。另外， catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且，拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地， mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间， catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少，并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时，线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态，和这可能与它 mitochondrial 的规定有关熔化和分裂事件。" @default.
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- W3143921111 date "2015-01-01" @default.
- W3143921111 modified "2023-09-29" @default.
- W3143921111 title "Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction" @default.
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