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- W3143976409 abstract "Microspheres are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate ibuprofen microspheres by solvent evaporation method, with water insoluble polymers such as Ethyl cellulose and sodium carboxymethyl cellulose as suspending agent, using as carrier for oral administration in view to achieve oral sustained release of the drug. Ibuprofen is a non-steroidal antiinflammatory drug (NSAID) used for relief of signs and symptoms of rheumatoid arthritis, osteoarthritis and is used in chronic and acute conditions of pain and inflammation. Its biological half-life is 2 ±0.5 hrs. Due to its low biological half-life (2 hrs), it requires frequent administration to maintain plasma concentration. This causes inconvenience to the patient and also leads fluctuations in plasma drug concentration that may cause inferior therapeutic effects or toxic effects. There-fore, development of controlled release dosage forms would clearly be beneficial in terms of decreased dosage requirements, thus increase patient compliance. The formulations were evaluated for particle size distribution analysis, flow properties like Angle of repose, bulk density, tapped density, Hausner’s Ratio, Carr’s index, Encapsulation efficiency, Scanning electron microscopy, optical electron microscopy and invitro release studies. The optimized formulation showed good invitro sustained release activity of the drug ibuprofen." @default.
- W3143976409 created "2021-04-13" @default.
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- W3143976409 date "2014-01-01" @default.
- W3143976409 modified "2023-09-24" @default.
- W3143976409 title "Formulation and In Vitro Evaluation of Ibuprofen Loaded Ethyl Cellulose Microspheres" @default.
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