Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144009688> ?p ?o ?g. }
- W3144009688 abstract "Abstract Coronavirus Disease 2019 (COVID-19) severity and Diabetes mellitus affect each other bidirectionally. The plus-sense single-stranded RNA (+ssRNA) genome of the SARS-CoV-2 virus can be targeted and suppressed by the host cell’s microRNAs (miRNAs). Using the differential gene expression analysis between the mock-infected and the SARS-CoV-2-infected pancreatic tissue, we report five Diabetes-associated genes that are upregulated due to SARS-CoV-2 infection in the hESC pancreas tissues. Ten miRNAs regulating these five genes can potentially target the SARS-CoV-2 genome. We hypothesize that the SARS-CoV-2 genome copies in the infected human pancreas cell compete with the host cell’s native genes in being regulated by the native miRNAs. It leads to the reduced miRNA-regulation and, thus, the upregulation of the Diabetes-associated native genes. Thus, the resultant new-onset or elevated Diabetic symptoms may worsen the condition of COVID-19 patients." @default.
- W3144009688 created "2021-04-13" @default.
- W3144009688 creator A5036975750 @default.
- W3144009688 creator A5042692034 @default.
- W3144009688 creator A5044937052 @default.
- W3144009688 date "2021-03-31" @default.
- W3144009688 modified "2023-09-27" @default.
- W3144009688 title "Linking Diabetes mellitus to SARS-CoV-2 infection through differential targeting of the microRNAs in the Pancreas tissue" @default.
- W3144009688 cites W172947000 @default.
- W3144009688 cites W1901347259 @default.
- W3144009688 cites W1965064710 @default.
- W3144009688 cites W1968097298 @default.
- W3144009688 cites W1970707135 @default.
- W3144009688 cites W1985213868 @default.
- W3144009688 cites W2004267617 @default.
- W3144009688 cites W2019130238 @default.
- W3144009688 cites W2028689806 @default.
- W3144009688 cites W2048296798 @default.
- W3144009688 cites W2057072852 @default.
- W3144009688 cites W2076493816 @default.
- W3144009688 cites W2096583106 @default.
- W3144009688 cites W2101117089 @default.
- W3144009688 cites W2132258556 @default.
- W3144009688 cites W2133465414 @default.
- W3144009688 cites W2137734450 @default.
- W3144009688 cites W2140158862 @default.
- W3144009688 cites W2144656637 @default.
- W3144009688 cites W2154567689 @default.
- W3144009688 cites W2159675211 @default.
- W3144009688 cites W2165916864 @default.
- W3144009688 cites W2288482887 @default.
- W3144009688 cites W2416046640 @default.
- W3144009688 cites W2507345512 @default.
- W3144009688 cites W2701492706 @default.
- W3144009688 cites W2891009119 @default.
- W3144009688 cites W2950221693 @default.
- W3144009688 cites W2950993016 @default.
- W3144009688 cites W2970358232 @default.
- W3144009688 cites W3003217347 @default.
- W3144009688 cites W3011152298 @default.
- W3144009688 cites W3020440274 @default.
- W3144009688 cites W3033126715 @default.
- W3144009688 cites W3034708975 @default.
- W3144009688 cites W3035586023 @default.
- W3144009688 cites W3036500399 @default.
- W3144009688 cites W3103861847 @default.
- W3144009688 cites W4206161223 @default.
- W3144009688 doi "https://doi.org/10.1101/2021.03.31.437823" @default.
- W3144009688 hasPublicationYear "2021" @default.
- W3144009688 type Work @default.
- W3144009688 sameAs 3144009688 @default.
- W3144009688 citedByCount "0" @default.
- W3144009688 crossrefType "posted-content" @default.
- W3144009688 hasAuthorship W3144009688A5036975750 @default.
- W3144009688 hasAuthorship W3144009688A5042692034 @default.
- W3144009688 hasAuthorship W3144009688A5044937052 @default.
- W3144009688 hasBestOaLocation W31440096881 @default.
- W3144009688 hasConcept C104317684 @default.
- W3144009688 hasConcept C126322002 @default.
- W3144009688 hasConcept C127561419 @default.
- W3144009688 hasConcept C134018914 @default.
- W3144009688 hasConcept C141231307 @default.
- W3144009688 hasConcept C145059251 @default.
- W3144009688 hasConcept C159047783 @default.
- W3144009688 hasConcept C2778764654 @default.
- W3144009688 hasConcept C2779134260 @default.
- W3144009688 hasConcept C54355233 @default.
- W3144009688 hasConcept C555293320 @default.
- W3144009688 hasConcept C71924100 @default.
- W3144009688 hasConcept C86803240 @default.
- W3144009688 hasConceptScore W3144009688C104317684 @default.
- W3144009688 hasConceptScore W3144009688C126322002 @default.
- W3144009688 hasConceptScore W3144009688C127561419 @default.
- W3144009688 hasConceptScore W3144009688C134018914 @default.
- W3144009688 hasConceptScore W3144009688C141231307 @default.
- W3144009688 hasConceptScore W3144009688C145059251 @default.
- W3144009688 hasConceptScore W3144009688C159047783 @default.
- W3144009688 hasConceptScore W3144009688C2778764654 @default.
- W3144009688 hasConceptScore W3144009688C2779134260 @default.
- W3144009688 hasConceptScore W3144009688C54355233 @default.
- W3144009688 hasConceptScore W3144009688C555293320 @default.
- W3144009688 hasConceptScore W3144009688C71924100 @default.
- W3144009688 hasConceptScore W3144009688C86803240 @default.
- W3144009688 hasLocation W31440096881 @default.
- W3144009688 hasLocation W31440096882 @default.
- W3144009688 hasOpenAccess W3144009688 @default.
- W3144009688 hasPrimaryLocation W31440096881 @default.
- W3144009688 hasRelatedWork W2030640333 @default.
- W3144009688 hasRelatedWork W2034240320 @default.
- W3144009688 hasRelatedWork W2093977802 @default.
- W3144009688 hasRelatedWork W2171277769 @default.
- W3144009688 hasRelatedWork W2594860815 @default.
- W3144009688 hasRelatedWork W2987613293 @default.
- W3144009688 hasRelatedWork W3033389342 @default.
- W3144009688 hasRelatedWork W3150490778 @default.
- W3144009688 hasRelatedWork W3154489017 @default.
- W3144009688 hasRelatedWork W4361261938 @default.
- W3144009688 isParatext "false" @default.
- W3144009688 isRetracted "false" @default.
- W3144009688 magId "3144009688" @default.