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- W3144021604 abstract "Until recently, the sequestration of erythrocytes infected with Plasmodium falciparum has been thmtght to be due to one of a mmt#er of protein-proteh~ interactions, hl this artick,, Stephe, Ro~erson and Graham Brow,i summarize the emerging evidence that, in vitro, i':f,-cted erythrocytes can al~ adhere to the ~h/cosaminoglycan chondwitin sul- phate A (CSA) expressed on the sur}'~ce of cells and immo- bilized on plastic. In vivo, binding of infected erythrocytes to CSA co;:ld Ire crucial to the development Of malarial infection of the placenta, and possihly to sequestraSon in the lung and brain. The consequences of this may include maternal morbhlity and mortality, 16,zo birth weight in the fllfant, pulmo,ary oedema and cerebral malarh~. They dis- cuss the need io characterize the molecular basis of this interaction, and to investigate the possible therapeutic role of CSA in malaria. Chondroitin sulphates are nontoxic compounds already iu use for other diseases in hmnans. Vaccim~ ba~d on inhibithlg this receptor-ligand h#eraction could al~ be appropriate. Sequestration of mature parasites in deep tissues is a key feature of the replication of Plasmodim, falciporum infection. Sequestration of parasitized red blood cells (PRBC) in the brain and in the placei-tta appears to be crucial to the development of cerebral ~alaria and complications of malaria in pregnancy. It is clear that several different host molecules can act as receptors for PRBC in vitro. These include thrombospondin (TSPp, CD36 (Re/. 2), intercellular adhesion molecule 1 (ICAM-1) 3, E-selectha and vascular cell adhesion molecule 1 (Ref. 4). When isolates from patients have been studied, it has born difficult to correlate ad- hesion to any of these receptors with disease severity, and only one study has found an association between adhesion to C32 melanoma cells and severe disease s. Evidence has pointed to the existence of other recep- tors, on microvascular endothelial cells 6, C32 mela- noma cells z, human umbilical vein endothelial cells (HUVEC) s and on 5aimiri monkey brain endothelial ceils ($BEC) 9." @default.
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- W3144021604 date "1997-01-01" @default.
- W3144021604 modified "2023-09-27" @default.
- W3144021604 title "Chondroit(n Sulphate A as an Adherence Receptor for Plasmodium faiciparum.infected Erythrocytes" @default.
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