FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144022425> ?p ?o ?g. }

• W3144022425 endingPage "266" @default.
• W3144022425 startingPage "257" @default.
• W3144022425 abstract "In parallel with the improvement of living standard, Non-alcoholic fatty liver disease (NAFLD) becomes the most common liver disease around the world. Huazhi Fugan Granules (HZFGG) is a formula which is used to treating of fatty liver, Based on the data we studied, HZFGG may have potential as a therapeutic formula for the alleviation of NAFLD.The aim of our study was to identifying the improvement of HZFGG on NAFLD and exploring the potential mechanisms.MCD diet fed C57BL/6 mice once a day for 4 weeks to induce NAFLD model, HZFGG (10, 15, 20g/kg) orally administered simultaneously. The serum levels of TC, TG, ALT, AST were detected. H&E and Oil Red O staining were used to observed the liver sections. TNF-α, IL-1β and Gpx were also detected. The expression levels of TLR4, MyD88, p-NF-κB, NF-κB, p-IκBa were measured by western blotting assay. The apoptosis of the liver tissues were detected by TUNEL assay.HZFGG decreased the serum levels of TC, TG, ALT, AST in MCD-diet mice. HZFGG alleviated inflammation by decreasing the levels of TNF-α and IL-1β and ameliorated oxidative stress through increased the level of Gpx. HZFGG Attenuates MCD-induced liver steatosis and injury in mice. Hepatocyte apoptosis was decreased after HZFGG treatment. Furthermore, HZFGG also suppressed the expression levels of TLR4 and MyD88, subsequently, inhibited the phosphorylation of NF-κB and IκBa.HZFGG can improved MCD induced hepatic injury through inhibited TLR4/NF-κB signaling pathway in NAFLD model." @default.
• W3144022425 created "2021-04-13" @default.
• W3144022425 creator A5010989186 @default.
• W3144022425 creator A5015113336 @default.
• W3144022425 creator A5027570906 @default.
• W3144022425 creator A5038282329 @default.
• W3144022425 creator A5059273714 @default.
• W3144022425 creator A5060167694 @default.
• W3144022425 creator A5072529270 @default.
• W3144022425 creator A5081300658 @default.
• W3144022425 creator A5086790602 @default.
• W3144022425 date "2021-09-01" @default.
• W3144022425 modified "2023-09-27" @default.
• W3144022425 title "Alleviation of non-alcoholic fatty liver disease by Huazhi Fugan Granules is associated with suppression of TLR4/NF-κB signaling pathway" @default.
• W3144022425 cites W1491764483 @default.
• W3144022425 cites W1967972402 @default.
• W3144022425 cites W1973978057 @default.
• W3144022425 cites W1977194186 @default.
• W3144022425 cites W1984821297 @default.
• W3144022425 cites W1988981256 @default.
• W3144022425 cites W2004465286 @default.
• W3144022425 cites W2013178634 @default.
• W3144022425 cites W2015376899 @default.
• W3144022425 cites W2018427433 @default.
• W3144022425 cites W2053026149 @default.
• W3144022425 cites W2067135721 @default.
• W3144022425 cites W2123824588 @default.
• W3144022425 cites W2204688218 @default.
• W3144022425 cites W2256856541 @default.
• W3144022425 cites W2273379630 @default.
• W3144022425 cites W2283843704 @default.
• W3144022425 cites W2285911646 @default.
• W3144022425 cites W2403366498 @default.
• W3144022425 cites W2466598932 @default.
• W3144022425 cites W2550695592 @default.
• W3144022425 cites W2597233011 @default.
• W3144022425 cites W2761478531 @default.
• W3144022425 cites W2770129291 @default.
• W3144022425 cites W2796239046 @default.
• W3144022425 cites W2805694785 @default.
• W3144022425 cites W2807938853 @default.
• W3144022425 cites W2810423511 @default.
• W3144022425 cites W2893707268 @default.
• W3144022425 cites W2896130110 @default.
• W3144022425 cites W2907493655 @default.
• W3144022425 cites W2946006649 @default.
• W3144022425 cites W2968678670 @default.
• W3144022425 cites W3012238932 @default.
• W3144022425 cites W3016052994 @default.
• W3144022425 cites W3032267617 @default.
• W3144022425 cites W3143453042 @default.
• W3144022425 cites W4245318832 @default.
• W3144022425 doi "https://doi.org/10.1016/j.arteri.2020.12.007" @default.
• W3144022425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33810882" @default.
• W3144022425 hasPublicationYear "2021" @default.
• W3144022425 type Work @default.
• W3144022425 sameAs 3144022425 @default.
• W3144022425 citedByCount "3" @default.
• W3144022425 countsByYear W31440224252021 @default.
• W3144022425 countsByYear W31440224252022 @default.
• W3144022425 crossrefType "journal-article" @default.
• W3144022425 hasAuthorship W3144022425A5010989186 @default.
• W3144022425 hasAuthorship W3144022425A5015113336 @default.
• W3144022425 hasAuthorship W3144022425A5027570906 @default.
• W3144022425 hasAuthorship W3144022425A5038282329 @default.
• W3144022425 hasAuthorship W3144022425A5059273714 @default.
• W3144022425 hasAuthorship W3144022425A5060167694 @default.
• W3144022425 hasAuthorship W3144022425A5072529270 @default.
• W3144022425 hasAuthorship W3144022425A5081300658 @default.
• W3144022425 hasAuthorship W3144022425A5086790602 @default.
• W3144022425 hasConcept C126322002 @default.
• W3144022425 hasConcept C134018914 @default.
• W3144022425 hasConcept C185592680 @default.
• W3144022425 hasConcept C190283241 @default.
• W3144022425 hasConcept C196795494 @default.
• W3144022425 hasConcept C202751555 @default.
• W3144022425 hasConcept C2776070231 @default.
• W3144022425 hasConcept C2776151105 @default.
• W3144022425 hasConcept C2776175330 @default.
• W3144022425 hasConcept C2776200302 @default.
• W3144022425 hasConcept C2776637226 @default.
• W3144022425 hasConcept C2776914184 @default.
• W3144022425 hasConcept C2777730290 @default.
• W3144022425 hasConcept C2778772119 @default.
• W3144022425 hasConcept C2779134260 @default.
• W3144022425 hasConcept C2779478299 @default.
• W3144022425 hasConcept C55493867 @default.
• W3144022425 hasConcept C71924100 @default.
• W3144022425 hasConceptScore W3144022425C126322002 @default.
• W3144022425 hasConceptScore W3144022425C134018914 @default.
• W3144022425 hasConceptScore W3144022425C185592680 @default.
• W3144022425 hasConceptScore W3144022425C190283241 @default.
• W3144022425 hasConceptScore W3144022425C196795494 @default.
• W3144022425 hasConceptScore W3144022425C202751555 @default.
• W3144022425 hasConceptScore W3144022425C2776070231 @default.
• W3144022425 hasConceptScore W3144022425C2776151105 @default.
• W3144022425 hasConceptScore W3144022425C2776175330 @default.
• W3144022425 hasConceptScore W3144022425C2776200302 @default.

• next