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- W3144025664 abstract "Type 2 diabetes (T2D) plays a major role in the development of heart failure. Patients with T2D have an increased risk to develop HF than healthy subjects, and they always have very poor outcomes and survival rates. However, the underlying mechanisms for this are still unclear. To help develop new therapeutic interventions, well-characterized animal models for preclinical and translational investigations in T2D and HF are urgently needed. Although studies in rodents are more often used, the research findings in rodents have often failed to be translated into humans due to the significant metabolic differences between rodents and humans. Nonhuman primates (NHPs) serve as valuable translational models between basic studies in rodent models and clinical studies in humans. NHPs can recapitulate the natural progress of these diseases in humans and study the underlying mechanism due to their genetic similarity and comparable spontaneous T2D rates to humans. In this review, we discuss the importance of using NHPs models in understanding diabetic cardiomyopathy (DCM) in humans with aspects of correlations between hyperglycemia and cardiac dysfunction progression, glucose overload, and altered glucose metabolism promoting cardiac oxidative stress and mitochondria dysfunction, glucose, and its effect on cardiac resynchronization therapy with defibrillator (CRT-d), the currently available diabetic NHPs models and the limitations involved in the use of NHP models." @default.
- W3144025664 created "2021-04-13" @default.
- W3144025664 creator A5015311491 @default.
- W3144025664 creator A5052655646 @default.
- W3144025664 creator A5064876504 @default.
- W3144025664 date "2021-03-30" @default.
- W3144025664 modified "2023-10-10" @default.
- W3144025664 title "A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates" @default.
- W3144025664 cites W1505433241 @default.
- W3144025664 cites W1529989533 @default.
- W3144025664 cites W161765618 @default.
- W3144025664 cites W1855276256 @default.
- W3144025664 cites W1962981647 @default.
- W3144025664 cites W1970580387 @default.
- W3144025664 cites W1974939683 @default.
- W3144025664 cites W1977040679 @default.
- W3144025664 cites W1977319818 @default.
- W3144025664 cites W1977810453 @default.
- W3144025664 cites W1979595579 @default.
- W3144025664 cites W1984794792 @default.
- W3144025664 cites W1986276307 @default.
- W3144025664 cites W1986721569 @default.
- W3144025664 cites W1987981915 @default.
- W3144025664 cites W1992856669 @default.
- W3144025664 cites W1997930168 @default.
- W3144025664 cites W2000325349 @default.
- W3144025664 cites W2000812766 @default.
- W3144025664 cites W2001022546 @default.
- W3144025664 cites W2003015396 @default.
- W3144025664 cites W2006247039 @default.
- W3144025664 cites W2010169277 @default.
- W3144025664 cites W2016015885 @default.
- W3144025664 cites W2024201973 @default.
- W3144025664 cites W2025446061 @default.
- W3144025664 cites W2030196870 @default.
- W3144025664 cites W2033551842 @default.
- W3144025664 cites W2033875805 @default.
- W3144025664 cites W2054042932 @default.
- W3144025664 cites W2056298675 @default.
- W3144025664 cites W2058536977 @default.
- W3144025664 cites W2059537042 @default.
- W3144025664 cites W2069671127 @default.
- W3144025664 cites W2070647639 @default.
- W3144025664 cites W2072203364 @default.
- W3144025664 cites W2074528335 @default.
- W3144025664 cites W2077702391 @default.
- W3144025664 cites W2080174452 @default.
- W3144025664 cites W2083993817 @default.
- W3144025664 cites W2098437467 @default.
- W3144025664 cites W2102147313 @default.
- W3144025664 cites W2103642791 @default.
- W3144025664 cites W2106842409 @default.
- W3144025664 cites W2107487658 @default.
- W3144025664 cites W2107516773 @default.
- W3144025664 cites W2122272758 @default.
- W3144025664 cites W2124069357 @default.
- W3144025664 cites W2129983555 @default.
- W3144025664 cites W2139618637 @default.
- W3144025664 cites W2140704600 @default.
- W3144025664 cites W2145397929 @default.
- W3144025664 cites W2148135522 @default.
- W3144025664 cites W2153092921 @default.
- W3144025664 cites W2158184576 @default.
- W3144025664 cites W2162595307 @default.
- W3144025664 cites W2166988806 @default.
- W3144025664 cites W2168974362 @default.
- W3144025664 cites W2169299320 @default.
- W3144025664 cites W2170971994 @default.
- W3144025664 cites W2171553260 @default.
- W3144025664 cites W2289823333 @default.
- W3144025664 cites W2315104804 @default.
- W3144025664 cites W2343155499 @default.
- W3144025664 cites W2398601468 @default.
- W3144025664 cites W2399659685 @default.
- W3144025664 cites W2412117889 @default.
- W3144025664 cites W2413141467 @default.
- W3144025664 cites W2444268874 @default.
- W3144025664 cites W2498465912 @default.
- W3144025664 cites W2518231500 @default.
- W3144025664 cites W2533855169 @default.
- W3144025664 cites W2568435816 @default.
- W3144025664 cites W2572657306 @default.
- W3144025664 cites W2591558322 @default.
- W3144025664 cites W2597620906 @default.
- W3144025664 cites W2602475094 @default.
- W3144025664 cites W2604833931 @default.
- W3144025664 cites W2610519768 @default.
- W3144025664 cites W2614648545 @default.
- W3144025664 cites W2623880287 @default.
- W3144025664 cites W2734888049 @default.
- W3144025664 cites W2775005500 @default.
- W3144025664 cites W2787504330 @default.
- W3144025664 cites W2791011305 @default.
- W3144025664 cites W2806995641 @default.
- W3144025664 cites W2897826217 @default.
- W3144025664 cites W2898857789 @default.
- W3144025664 cites W2913709946 @default.
- W3144025664 cites W2916122595 @default.