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- W3144035189 abstract "BACKGROUNDStimulation of cardiac sympathetic afferents during myocardial ischemia has been attributed to bradykinin released from the ischemic myocardium. Recent data from human studies suggest that adenosine may serve as this mediator. Our experiments were done to determine whether reflex sympathoexcitatory responses to activation of cardiac sympathetic afferents during myocardial ischemia could be inhibited by blockade of adenosine receptors and augmented by increasing the local concentrations of adenosine in the ischemic myocardium.METHODS AND RESULTSExperiments were done in 29 anesthetized dogs with bilateral vagotomy and carotid sinus denervation. Activation of cardiac sympathetic afferent fibers was induced by occlusion of the left anterior descending coronary artery (LAD) combined with rapid atrial pacing (pacing rate, 200 beats per minute). LAD occlusion plus rapid atrial pacing increased renal sympathetic nerve activity by 20 +/- 4% before but by only 7 +/- 1% after administration of aminophyllin..." @default.
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- W3144035189 date "1993-01-01" @default.
- W3144035189 modified "2023-09-24" @default.
- W3144035189 title "Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine." @default.
- W3144035189 hasPublicationYear "1993" @default.
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