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- W3144055745 abstract "1111-Symp Origin and Mechanism of Mitochondrial Flashes Heping Cheng1,2, Xianhua Wang1,2, Qi Ma1,2, Wang Wang3,4. Inst Molec Med, Peking Univ, Beijing, China, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking-Tsinghua Center for Life Sciences, Beijing, China, Mitochondria and Metabolism Center, University of Washington, Seattle, WA, USA, Department of Anesthesiology and Pain Medicine, Seattle, WA, USA. Respiratory mitochondria spontaneously undergo quantal, brief bursts of production, named superoxide flashes. A property common to all species and cell types examined, the generation of flashes is coupled to transient opening of the mitochondrial membrane permeability transition pore and depends on the functional integrity of the electrontransfer chain (ETC). The unitary properties of flashes (amplitude and duration) appear to be stereotypical, at levels from isolated mitochondria to whole organs (e.g. the beating heart) and even to live animals. Functionally, flashes act as elemental reactive oxygen species (ROS) signaling events (signaling ROS) that participate in diverse cellular processes, whereas the constitutive electron leakage of molecular oxygen from the ETC produces the bulk of ROS for the regulation of redox homeostasis (homeostatic ROS). In particular, flash incidence provides a digital readout to gauge glucoseand insulin-stimulated mitochondrial metabolism in live animals, and a novel biomarker of the oxidative stress in hyperosmotic stress, ischemia-reperfusion injury, and neurodegenerative diseases. Such dynamic, locally-high levels of ROS in the form of flashes constitute one of the earliest signals that initiate the cell-death program without appreciably affecting the global ROS level. Moreover, in contrast to the effects of global ROS, flashes negatively regulate neuronal progenitor cell self-renewal in the developing cerebral cortex. Thus, recent advances in flashology have bolstered the notion that ROS act as second messengers in physiological and pathophysiological contexts, and demonstrate the paramount importance of the spatiotemporal organization of ROS signals in determining their signaling efficiency and modality." @default.
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- W3144055745 date "2014-01-01" @default.
- W3144055745 modified "2023-09-23" @default.
- W3144055745 title "Regulation of Voltage-Gated Calcium Channel Trafficking and Function by Auxiliary Subunits" @default.
- W3144055745 hasPublicationYear "2014" @default.
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