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- W3144064791 endingPage "149" @default.
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- W3144064791 abstract "Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these secreted molecules evoke sustained autophagy in a variety of cell types, tissues, and model systems. The unique properties of proteoglycans have ushered in a paradigmatic shift to broaden our understanding of matrix-mediated signaling cascades. The dynamic cellular pathway controlling autophagy is now linked to an equally dynamic and fluid signaling network embedded in a complex meshwork of matrix molecules. A rapidly emerging field of research encompasses multiple matrix-derived candidates, representing a menagerie of soluble matrix constituents including decorin, biglycan, endorepellin, endostatin, collagen VI and plasminogen kringle 5. These matrix constituents are pro-autophagic and simultaneously anti-angiogenic. In contrast, perlecan, laminin α2 chain, and lumican have anti-autophagic functions. Mechanistically, each matrix constituent linked to intracellular catabolic events engages a specific cell surface receptor that often converges on a common core of the autophagic machinery including AMPK, Peg3 and Beclin 1. We consider this matrix-evoked autophagy as non-canonical given that it occurs in an allosteric manner and is independent of nutrient availability or prevailing bioenergetics control. We propose that matrix-regulated autophagy is an important outside-in signaling mechanism for proper tissue homeostasis that could be therapeutically leveraged to combat a variety of diseases." @default.
- W3144064791 created "2021-04-13" @default.
- W3144064791 creator A5036208680 @default.
- W3144064791 creator A5038861339 @default.
- W3144064791 creator A5051174751 @default.
- W3144064791 creator A5065094098 @default.
- W3144064791 creator A5084413995 @default.
- W3144064791 date "2021-06-01" @default.
- W3144064791 modified "2023-10-16" @default.
- W3144064791 title "A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy" @default.
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