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- W3144156761 abstract "BACKGROUNDEpinephrine and mental stress may, via platelet stimulation, enhance the risk of thrombus formation. Norepinephrine is more likely than epinephrine to activate platelets in vivo because of higher levels in plasma but is less well studied in this respect. The antiplatelet drug of choice for patients with coronary artery disease, aspirin, may be less effective during sympathoadrenal activation. We therefore investigated platelet responses in vivo to exogenous norepinephrine with and without aspirin pretreatment.METHODS AND RESULTSPlatelet aggregability in vivo was assessed in 11 healthy male subjects, by filtragometry ex vivo (which reflects platelet aggregability in vivo) and by measurements of plasma beta-thromboglobulin (beta-TG, which reflects platelet secretion). Norepinephrine infusions elevated venous plasma norepinephrine from 1.5 to 4 and 15 nmol/L, respectively, and enhanced platelet aggregability (filtragometry) concentration dependently (P < .001). Platelet secretion (beta-TG levels) i..." @default.
- W3144156761 created "2021-04-13" @default.
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- W3144156761 date "1994-01-01" @default.
- W3144156761 modified "2023-09-23" @default.
- W3144156761 title "Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin." @default.
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