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- W3144162093 abstract "分成三部分的主题(修剪) 家庭蛋白质是戒指手指包含域，多域蛋白质在许多生物过程含有。包括 TRIM-9， MID1 和 MID2，整齐的蛋白质的 TRIM-9/C-I 亚科的成员有 neuronal 功能并且与神经病学的疾病被联系。为了探索 C-I 的功能是否整修蛋白质，在无脊椎动物被保存，我们分析了 Caenorhabditis elegans 和果蝇 trim-9 异种。C。elegans trim-9 异种在雌雄同体的腹的指导展出缺点特定的神经原(HSN ) 和触摸神经原 AVM。进一步基因的分析显示 TRIM-9 参予 UNC-6-UNC-40 吸引力小径。UNC-40 的不对称的分发在 trim-9 异种在 HSN 开发期间是正常的。然而， MIG-10 的不对称的本地化， UNC-40 的一个下游的受动器，在 trim-9 异种被废除。这些结果建议 TRIM-9 工作在 UNC-40 小径的 MIG-10 在上游。而且，我们证明在 vitro 的 TRIM-9 展览 E3 ubiquitin ligase 活动和这项活动为在 vivo 的 TRIM-9 功能是重要的。另外，我们发现果蝇 trim-9 为一组感觉神经原轴突的中线吸引力被要求。Netrin/UNC-6 受体的在表示上穿破在 trim-9 异种压制指导缺点。我们的学习在 UNC-40/Frazzled-mediated UNC-6/Netrin 吸引力小径揭示 TRIM-9 的 evolutionarily 保存的功能。" @default.
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- W3144162093 date "2011-01-01" @default.
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- W3144162093 title "TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance" @default.
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