FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144175829> ?p ?o ?g. }

• W3144175829 endingPage "145617" @default.
• W3144175829 startingPage "145617" @default.
• W3144175829 abstract "Abstract Background IL-1β and TNF-α have been demonstrated as pro-inflammatory cytokines to participate in the innate immune response and suppression of HBV infection. However, the exact relationship between IL-1β, TNF-α gene polymorphisms and HBV infection remains unknown. Our study aims to assess the associations between IL-1β, TNF-α gene polymorphisms and HBV infection. Methods A systematic literature search of PubMed and Embase databases was conducted through February 2020, and studies that were included in the present meta-analysis should fulfil the following conditions: (1) case-control studies focusing on the associations between IL-1β, TNF-α polymorphisms and HBV infection; (2) patients in the case group should be tested positive for the HBsAg and/or HBV-DNA without liver cirrhosis or hepatocellular carcinoma; (3) the control group including healthy population or HBV spontaneous clearance population; (4) odds ratios (ORs) and their 95% confidence intervals (CIs) could be calculated based on the allele and genotype frequencies provided in articles. The quality of included studies was assessed according to the Newcastle-Ottawa scale (NOS) assessment system. Pooled ORs and 95% CIs were used to analyze the strength of associations. Subgroup analysis was performed according to ethnicity and control type. Results In the present meta-analysis, 49 articles including 10,218 cases and 9,557 controls were enrolled and seven polymorphisms (IL-1β rs16944, rs1143634, TNF-α rs1799724, rs1799964, rs1800629, rs1800630, rs361525) were studied. In overall meta-analysis, significant associations were found in IL-1β rs1143634, TNF-α rs1799724 and TNF-α rs1799964. For subgroup analysis under ethnicity, TNF-α rs1799724 and rs1800630 were markedly related to HBV infection in both Asian and Caucasian populations. In terms of control type subgroup, TNF-α rs1799724, rs1799964, rs1800630 were significantly associated with HBV persistence in HBV spontaneous clearance group. Conclusion In the present study, we identified that three polymorphisms (IL-1β rs1143634, TNF-α rs1799724, rs1799964) might serve as potential genetic biomarkers in HBV infection." @default.
• W3144175829 created "2021-04-13" @default.
• W3144175829 creator A5029169943 @default.
• W3144175829 creator A5034762794 @default.
• W3144175829 creator A5038316011 @default.
• W3144175829 creator A5066568560 @default.
• W3144175829 creator A5075753229 @default.
• W3144175829 creator A5076136758 @default.
• W3144175829 date "2021-07-01" @default.
• W3144175829 modified "2023-10-03" @default.
• W3144175829 title "Relationships between IL-1β, TNF-α genetic polymorphisms and HBV infection: A meta-analytical study" @default.
• W3144175829 cites W1799137450 @default.
• W3144175829 cites W1966564623 @default.
• W3144175829 cites W1970791171 @default.
• W3144175829 cites W1980066896 @default.
• W3144175829 cites W1982923741 @default.
• W3144175829 cites W2013337497 @default.
• W3144175829 cites W2053172006 @default.
• W3144175829 cites W2086289604 @default.
• W3144175829 cites W2102611835 @default.
• W3144175829 cites W2108652447 @default.
• W3144175829 cites W2109083225 @default.
• W3144175829 cites W2148525723 @default.
• W3144175829 cites W2157177585 @default.
• W3144175829 cites W2277297461 @default.
• W3144175829 cites W2542287135 @default.
• W3144175829 cites W2560475594 @default.
• W3144175829 cites W2561876393 @default.
• W3144175829 cites W2562951319 @default.
• W3144175829 cites W2566317001 @default.
• W3144175829 cites W2610554395 @default.
• W3144175829 cites W2611433017 @default.
• W3144175829 cites W2612661120 @default.
• W3144175829 cites W2619899589 @default.
• W3144175829 cites W2621560360 @default.
• W3144175829 cites W2761322507 @default.
• W3144175829 cites W2771968994 @default.
• W3144175829 cites W2794148516 @default.
• W3144175829 cites W2804281681 @default.
• W3144175829 cites W2862189625 @default.
• W3144175829 cites W2888462695 @default.
• W3144175829 cites W2895014452 @default.
• W3144175829 cites W2896278355 @default.
• W3144175829 cites W2905256698 @default.
• W3144175829 cites W2908892347 @default.
• W3144175829 cites W2909432303 @default.
• W3144175829 cites W2914191085 @default.
• W3144175829 cites W2969620792 @default.
• W3144175829 cites W3000192826 @default.
• W3144175829 cites W4241322069 @default.
• W3144175829 doi "https://doi.org/10.1016/j.gene.2021.145617" @default.
• W3144175829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33775848" @default.
• W3144175829 hasPublicationYear "2021" @default.
• W3144175829 type Work @default.
• W3144175829 sameAs 3144175829 @default.
• W3144175829 citedByCount "9" @default.
• W3144175829 countsByYear W31441758292022 @default.
• W3144175829 countsByYear W31441758292023 @default.
• W3144175829 crossrefType "journal-article" @default.
• W3144175829 hasAuthorship W3144175829A5029169943 @default.
• W3144175829 hasAuthorship W3144175829A5034762794 @default.
• W3144175829 hasAuthorship W3144175829A5038316011 @default.
• W3144175829 hasAuthorship W3144175829A5066568560 @default.
• W3144175829 hasAuthorship W3144175829A5075753229 @default.
• W3144175829 hasAuthorship W3144175829A5076136758 @default.
• W3144175829 hasConcept C159047783 @default.
• W3144175829 hasConcept C17991360 @default.
• W3144175829 hasConcept C203014093 @default.
• W3144175829 hasConcept C54355233 @default.
• W3144175829 hasConcept C70721500 @default.
• W3144175829 hasConcept C86803240 @default.
• W3144175829 hasConceptScore W3144175829C159047783 @default.
• W3144175829 hasConceptScore W3144175829C17991360 @default.
• W3144175829 hasConceptScore W3144175829C203014093 @default.
• W3144175829 hasConceptScore W3144175829C54355233 @default.
• W3144175829 hasConceptScore W3144175829C70721500 @default.
• W3144175829 hasConceptScore W3144175829C86803240 @default.
• W3144175829 hasLocation W31441758291 @default.
• W3144175829 hasOpenAccess W3144175829 @default.
• W3144175829 hasPrimaryLocation W31441758291 @default.
• W3144175829 hasRelatedWork W1702322095 @default.
• W3144175829 hasRelatedWork W1865764402 @default.
• W3144175829 hasRelatedWork W1975114493 @default.
• W3144175829 hasRelatedWork W1991523530 @default.
• W3144175829 hasRelatedWork W2002128513 @default.
• W3144175829 hasRelatedWork W2020824267 @default.
• W3144175829 hasRelatedWork W2075354549 @default.
• W3144175829 hasRelatedWork W2118087741 @default.
• W3144175829 hasRelatedWork W3029386773 @default.
• W3144175829 hasRelatedWork W2092874662 @default.
• W3144175829 hasVolume "791" @default.
• W3144175829 isParatext "false" @default.
• W3144175829 isRetracted "false" @default.
• W3144175829 magId "3144175829" @default.
• W3144175829 workType "article" @default.