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• W3144182010 abstract "We have demonstrated the neuroprotection of hydrogen sulfide (H2S) against chemical hypoxia-induced injury by inhibiting p38MAPK pathway. The present study attempts to evaluate the effect of H2S on chemical hypoxia-induced inflammation responses and its mecha- nisms in PC12 cells. We found that treatment of PC12 cells with cobalt chloride (CoCl2, a hypoxia mimetic agent) enhanced IL-6 secretion, nitric oxide (NO) gener- ation and expression levels of inducible nitric oxide syn- thase (iNOS) and neuronal nitric oxide synthase (nNOS). L-canavanine, a selective iNOS inhibitor, partly blocked CoCl2-induced cytotoxicity, apoptosis and mitochondrial insult. In addition, 7-Nitroindazole (7-NI), an inhibitor of nNOS, also partly attenuated the CoCl2-induced cyto- toxicity. The inhibition of p38MAPK by SB203580 (a selective p38MAPK inhibitor) or genetic silencing of p38MAPK by RNAi (Si-p38) depressed not only CoCl2 -induced iNOS expression, NO production, but also IL-6 secretion. In addition, N-acetyl-L-cysteine, a reactive oxygen species (ROS) scavenger, conferred a similar protective effect of SB203580 or Si-p38 against CoCl2- induced inflammatory responses. Importantly, pretreat- ment of PC12 cells with exogenous application of sodium hydrosulfide (a H2S donor, 400 lmol/l) for 30 min before exposure to CoCl2 markedly attenuated chemical hypoxia- stimulated iNOS and nNOS expression, NO generation and IL-6 secretion as well as p38MAPK phosphorylation in PC12 cells. Taken together, we demonstrated that p38MAPK-iNOS pathway contributes to chemical hypoxia-induced inflammation and that H2S produces an anti-inflammatory effect in chemical hypoxia-stimulated PC12 cells, which may be partly due to inhibition of ROS- activated p38MAPK-iNOS pathway." @default.
• W3144182010 created "2021-04-13" @default.
• W3144182010 creator A5021889576 @default.
• W3144182010 creator A5045084863 @default.
• W3144182010 date "2013-01-01" @default.
• W3144182010 modified "2023-09-27" @default.
• W3144182010 title "Inhibition of ROS-Activated p38MAPK Pathway is Involved in the Protective Effect of H 2 S Against Chemical Hypoxia-Induced Inflammation in PC12 Cells" @default.
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