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• W3144183886 abstract "(Accepted 22 November 2006; first published online 12 February 2007)SUMMARYThere are no data on the serotypes of rotaviruses prevalent in Kuwait, which has a largeexpatriate population and hence a focal point for transmission of pathogens. The serotypeinformation will contribute to the fund of knowledge on the world epidemiology of rotavirusserotypes and will predict the outcome of vaccination in Kuwait. Of the 75 rotavirus-positivesamples from 172 children (aged <5 years) with severe diarrhoea, 69 were genotyped. Thedistribution of genotypes was G1 (63.8%) followed by G9 (10.2%), G2 (7.3%), G4 (7.3%)andG3 (4.4%). Among the P types, P[8] was the most common type found across all G types. Byfluorescent focus neutralization test, serum antibodies to genotypes G1 (94%), G4 (68%) and G9(46%) were found in 120 other children. These results show that G1 is the predominant serotypein Kuwait and that a vaccine that contains G1 will be most effective.INTRODUCTIONRotavirus (RV) is one the most significant causesof infantile diarrhoea throughout the world. In de-veloping countries, 1 in every 100–200 children dies ofRV disease by 5 years of age [1, 2]. In industrializedcountries, the burden of RV is underlined by the highrate of hospitalization, and clinic and emergency-room visits [3]. An economic analysis in the UnitedStates estimated that RV disease costs the economymore than one billion dollars annually [4]. The goal toreduce the number of deaths in developing countries,and to cut the high cost of hospitalization in devel-oped countries, can only be achieved by introducinga RV vaccine into the childhood vaccination pro-gramme [5, 6]. However, since there are differencesin the regional and temporal distribution of RVsero/genotypes [7], it is important to conduct surveyson the prevalence of RV antibodies and determine thegenotypes present in a given area.Three of the seven RV groups are known toinfect the humans. Among them, the most dominantis group A, which causes diarrhoeal diseases world-wide [8].RV is a triple-layered, non-enveloped virus with adouble-stranded, segmented RNA genome. Of the 11genomic segments, segment 6 codes for the mostabundant viral protein, VP6. This is the major anti-genic determinant ofgroup A reactivity and the targetof common diagnostic assays. Segments 7, 8 or 9codes for the major glycoprotein, VP7, which is thebasisforRVserotyping.There are14Gserotypesand11 of them have been recovered from humans. Themajority of human RVs belong to serotypes G1–G4and to the newly emerged G9. G sero/genotypes aresynonymous. Segment 4 codes for a protease-sensitiveprotein, VP4, which is the basis for P-serotyping. Outof the 26 P genotypes reported, only 12 of them have" @default.
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• W3144183886 date "2007-01-01" @default.
• W3144183886 modified "2023-09-27" @default.
• W3144183886 title "Genotypic characterization of rotaviruses and prevalence of serotype-specific serum antibodies in children in Kuwait" @default.
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