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- W3144191927 abstract "植物 homeodomain (哲学博士) 手指在许多染色质绑定蛋白质被识别，并且作为 recognizesspecific epigenetic 在 histone 尾巴上标记的一个阅读器工作，衔接到染色质的抄写因素和他们的联系建筑群， andregulating 基因表示。哲学博士包含手指的蛋白质执行许多生物功能并且包括癌症涉及许多 humandiseases。PHF14 用多重哲学博士手指为蛋白质被预言到代码。然而，它的功能是未辩别出的。这 studyis 到的目的描绘 PHF14 并且由包括老鼠 gene-targetingknockout，并且分子的克隆和描述采用多重途径调查它的生物意义。在人的房间行的 PHF14 的三个抄本被反向的 transcriptase 聚合酶链反应识别。PHF14 (PHF14 和 PHF14 ) 的二 isoforms 在这研究被克隆。PHF14 无所不在地在老鼠纸巾和人的房间行被表示，这被发现。PHF14， PHF14 的主要 isoform，在原子核是局部性的并且也在房间分割期间跳了到染色质。有趣地， co-immunoprecipitation 结果建议 PHF14 经由它的哲学博士手指跳了到 histones。惊人地，在老鼠的 PHF14 的指向基因的大美人由于呼吸失败导致了新生的致命性。病理学的分析在多重机关揭示了 tissueand 房间结构的严重混乱，特别地在肺。这些结果显示 PHF14 可能是 epigeneticregulator 并且在鼠标在多重机关的开发起一个重要作用。" @default.
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- W3144191927 date "2013-01-01" @default.
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- W3144191927 title "Depletion ofPHF14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure" @default.
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