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- W3144201510 abstract "One of the major Ca 2+ signaling pathways is store-operated Ca 2+ entry (SOCE), which is responsible for Ca 2+ flow into cells in response to the depletion of endoplasmic reticulum Ca 2+ stores. SOCE and its molecular components, including stromal interaction molecule proteins, Orai Ca 2+ channels, and transient receptor potential canonical channels, are involved in the physiology of neural stem cells and play a role in their proliferation, differentiation, and neurogenesis. This suggests that Ca 2+ signaling is an important player in brain development. Huntington’s disease (HD) is an incurable neurodegenerative disorder that is caused by polyglutamine expansion in the huntingtin (HTT) protein, characterized by the loss of γ-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum. However, recent research has shown that HD is also a neurodevelopmental disorder and Ca 2+ signaling is dysregulated in HD. The relationship between HD pathology and elevations of SOCE was demonstrated in different cellular and mouse models of HD and in induced pluripotent stem cell-based GABAergic MSNs from juvenile- and adult-onset HD patient fibroblasts. The present review discusses the role of SOCE in the physiology of neural stem cells and its dysregulation in HD pathology. It has been shown that elevated expression of STIM2 underlying the excessive Ca 2+ entry through store-operated calcium channels in induced pluripotent stem cell-based MSNs from juvenile-onset HD. In the light of the latest findings regarding the role of Ca 2+ signaling in HD pathology we also summarize recent progress in the in vitro differentiation of MSNs that derive from different cell sources. We discuss advances in the application of established protocols to obtain MSNs from fetal neural stem cells/progenitor cells, embryonic stem cells, induced pluripotent stem cells, and induced neural stem cells and the application of transdifferentiation. We also present recent progress in establishing HD brain organoids and their potential use for examining HD pathology and its treatment. Moreover, the significance of stem cell therapy to restore normal neural cell function, including Ca 2+ signaling in the central nervous system in HD patients will be considered. The transplantation of MSNs or their precursors remains a promising treatment strategy for HD." @default.
- W3144201510 created "2021-04-13" @default.
- W3144201510 creator A5017946181 @default.
- W3144201510 creator A5062569825 @default.
- W3144201510 date "2021-04-01" @default.
- W3144201510 modified "2023-10-01" @default.
- W3144201510 title "Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington’s Disease" @default.
- W3144201510 cites W1441937161 @default.
- W3144201510 cites W1497938915 @default.
- W3144201510 cites W1575362995 @default.
- W3144201510 cites W1665753162 @default.
- W3144201510 cites W1845362415 @default.
- W3144201510 cites W1871335639 @default.
- W3144201510 cites W1889047426 @default.
- W3144201510 cites W1918236976 @default.
- W3144201510 cites W1934528477 @default.
- W3144201510 cites W1959262799 @default.
- W3144201510 cites W1967236853 @default.
- W3144201510 cites W1968053666 @default.
- W3144201510 cites W1975479233 @default.
- W3144201510 cites W1977632091 @default.
- W3144201510 cites W1978593035 @default.
- W3144201510 cites W1981720557 @default.
- W3144201510 cites W1982921572 @default.
- W3144201510 cites W1983313117 @default.
- W3144201510 cites W1985452716 @default.
- W3144201510 cites W1985958520 @default.
- W3144201510 cites W1988727978 @default.
- W3144201510 cites W1989113354 @default.
- W3144201510 cites W1991107962 @default.
- W3144201510 cites W1991686320 @default.
- W3144201510 cites W1992166970 @default.
- W3144201510 cites W1992813707 @default.
- W3144201510 cites W1993783504 @default.
- W3144201510 cites W1995658302 @default.
- W3144201510 cites W1998946448 @default.
- W3144201510 cites W2000396219 @default.
- W3144201510 cites W2001917660 @default.
- W3144201510 cites W2003829187 @default.
- W3144201510 cites W2005377272 @default.
- W3144201510 cites W2012458221 @default.
- W3144201510 cites W2014525534 @default.
- W3144201510 cites W2016354937 @default.
- W3144201510 cites W2018077381 @default.
- W3144201510 cites W2018286352 @default.
- W3144201510 cites W2020708758 @default.
- W3144201510 cites W2026139144 @default.
- W3144201510 cites W2026845803 @default.
- W3144201510 cites W2031958964 @default.
- W3144201510 cites W2034460442 @default.
- W3144201510 cites W2038901812 @default.
- W3144201510 cites W2046979739 @default.
- W3144201510 cites W2048432879 @default.
- W3144201510 cites W2049960163 @default.
- W3144201510 cites W2054153785 @default.
- W3144201510 cites W2055281290 @default.
- W3144201510 cites W2056720197 @default.
- W3144201510 cites W2057907154 @default.
- W3144201510 cites W2069798170 @default.
- W3144201510 cites W2069958858 @default.
- W3144201510 cites W2070375759 @default.
- W3144201510 cites W2075281619 @default.
- W3144201510 cites W2076969615 @default.
- W3144201510 cites W2077591858 @default.
- W3144201510 cites W2082314612 @default.
- W3144201510 cites W2085548169 @default.
- W3144201510 cites W2088449147 @default.
- W3144201510 cites W2088491939 @default.
- W3144201510 cites W2090018138 @default.
- W3144201510 cites W2095104495 @default.
- W3144201510 cites W2095650608 @default.
- W3144201510 cites W2096437759 @default.
- W3144201510 cites W2100316149 @default.
- W3144201510 cites W2101586949 @default.
- W3144201510 cites W2102446194 @default.
- W3144201510 cites W2106450957 @default.
- W3144201510 cites W2108488819 @default.
- W3144201510 cites W2109268486 @default.
- W3144201510 cites W2113998330 @default.
- W3144201510 cites W2114410594 @default.
- W3144201510 cites W2120564562 @default.
- W3144201510 cites W2121586624 @default.
- W3144201510 cites W2134031561 @default.
- W3144201510 cites W2134535346 @default.
- W3144201510 cites W2137258759 @default.
- W3144201510 cites W2138977668 @default.
- W3144201510 cites W2141578443 @default.
- W3144201510 cites W2143019545 @default.
- W3144201510 cites W2143737307 @default.
- W3144201510 cites W2149837988 @default.
- W3144201510 cites W2152069828 @default.
- W3144201510 cites W2157645703 @default.
- W3144201510 cites W2158561340 @default.
- W3144201510 cites W2161362481 @default.
- W3144201510 cites W2163789582 @default.
- W3144201510 cites W2168990206 @default.
- W3144201510 cites W2169413134 @default.
- W3144201510 cites W2170661153 @default.
- W3144201510 cites W2180157788 @default.
- W3144201510 cites W2187516654 @default.