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- W3144291048 abstract "The abuse of antibiotics has led to the emer- gence of many resistant bacteria, which threaten public health on a global scale. Conventional pipelines for anti- biotic discovery are gradually exhausted. Here a combi- natorial yeast overlay method is presented for the isolation of antibacterial oligopeptides. Three antibacterial dipeptide and tripeptides were discovered from 20 attempts, two of which possess glycosylation sites. Although the antibacte- rial effects were modest against several tested bacteria including a multi-resistant Staphylococcus aureus strain Y5, they are amenable to chemical modifications to enhance potency. This cost-effective method can circum- vent the expensive chemical peptide synthesis process. The eukaryotic host Saccharomyces cerevisiae adopted for peptide expression could serve as a surrogate biosafety assay system for antibacterial peptides. The small size of the oligopeptides render them attractive candidates for drug development. Given the vast combinatorial diversity of peptides, the reservoir may serve as a rich source of drug leads." @default.
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- W3144291048 date "2014-01-01" @default.
- W3144291048 modified "2023-09-26" @default.
- W3144291048 title "A Combinatorial Yeast Overlay Method for the Isolation of Antibacterial Oligopeptides" @default.
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