FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144318137> ?p ?o ?g. }

• W3144318137 abstract "Summary Resection of liver metastases in patients with colon cancer increases survival but success depends on removal of all tumour tissue. For this purpose, understanding of spatial relationships between metastases and liver architecture is essential. Because metastatic cancer growth is essentially a three-dimensional (3D) event, we decided to apply 3D reconstruction techniques to study these spatial relationships between metastases and liver structures such as blood vessels, stroma and the liver capsule (Glisson’s capsule). Colon carcinoma metastases were experimentally induced in rat liver by injection of colon cancer cells (CC531) into the portal vein. Three weeks later, livers from these animals and control livers were removed and immediately frozen in liquid nitrogen. Thirty-seven to 110 consecutive sections were used for each 3D reconstruction of 26 metastases in eight livers. Contours of different structures were stained by (immuno)histochemical means, traced in each section and stored in a database. From the contour model, a volume model was generated. Among the 26 metastases, seven were found to grow distantly from the liver capsule. They were small and consisted of well-differentiated cancer cells that were totally surrounded by a basement membrane and stroma which was always connected with adjacent blood vessels of a portal tract. The remaining 19 metastases showed a more advanced pattern of development. Infiltration of poorly differentiated colon cancer cells progressed through the stroma at various sites and areas of direct contact between cancer cells and hepatocytes were frequently found. This type of outgrowth of cancer cells was only found when metastases had made contact with the liver capsule. However, some areas in sections of these advanced stages still resembled small metastases. On the basis of these findings, we conclude that stroma affects the differentiation pattern of cancer cells and has at least a dual role in tumour growth. On the one hand it limits invasion of cancer cells in the surrounding host tissue. On the other hand, stroma formation at the capsule, which consists mainly of granulation tissue, facilitates outgrowth of the tumours. Furthermore, our 3D reconstructions demonstrate the spatial heterogeneity of larger metastases and the importance of a 3D approach to understand growth and development of metastases in general and colon cancer metastases in the liver in particular." @default.
• W3144318137 created "2021-04-13" @default.
• W3144318137 creator A5001230229 @default.
• W3144318137 creator A5084071486 @default.
• W3144318137 creator A5086484883 @default.
• W3144318137 date "1997-01-01" @default.
• W3144318137 modified "2023-09-27" @default.
• W3144318137 title "Three-dimensional reconstruction of colon carcinoma metastases in liver" @default.
• W3144318137 cites W1025362481 @default.
• W3144318137 cites W1029869927 @default.
• W3144318137 cites W142250820 @default.
• W3144318137 cites W1486773470 @default.
• W3144318137 cites W1560544667 @default.
• W3144318137 cites W1575420123 @default.
• W3144318137 cites W190178543 @default.
• W3144318137 cites W1949259756 @default.
• W3144318137 cites W1964975085 @default.
• W3144318137 cites W1966702041 @default.
• W3144318137 cites W1970104681 @default.
• W3144318137 cites W1973442480 @default.
• W3144318137 cites W1974731323 @default.
• W3144318137 cites W1975646837 @default.
• W3144318137 cites W1977932294 @default.
• W3144318137 cites W1980976772 @default.
• W3144318137 cites W1983916090 @default.
• W3144318137 cites W1984283473 @default.
• W3144318137 cites W1985341831 @default.
• W3144318137 cites W1992206665 @default.
• W3144318137 cites W1995034367 @default.
• W3144318137 cites W2019458163 @default.
• W3144318137 cites W2019931839 @default.
• W3144318137 cites W2020777583 @default.
• W3144318137 cites W2022652024 @default.
• W3144318137 cites W2026151657 @default.
• W3144318137 cites W2026806394 @default.
• W3144318137 cites W2028456177 @default.
• W3144318137 cites W2030065061 @default.
• W3144318137 cites W2038401422 @default.
• W3144318137 cites W2040200096 @default.
• W3144318137 cites W2040529976 @default.
• W3144318137 cites W2047619166 @default.
• W3144318137 cites W2057826623 @default.
• W3144318137 cites W2067392958 @default.
• W3144318137 cites W2067560990 @default.
• W3144318137 cites W2069663862 @default.
• W3144318137 cites W2076283983 @default.
• W3144318137 cites W2076414877 @default.
• W3144318137 cites W2091703426 @default.
• W3144318137 cites W2092858552 @default.
• W3144318137 cites W2095057859 @default.
• W3144318137 cites W2102513533 @default.
• W3144318137 cites W2107237937 @default.
• W3144318137 cites W2112587051 @default.
• W3144318137 cites W2113871210 @default.
• W3144318137 cites W2119231080 @default.
• W3144318137 cites W2122985113 @default.
• W3144318137 cites W2130850384 @default.
• W3144318137 cites W2156797391 @default.
• W3144318137 cites W2157031828 @default.
• W3144318137 cites W2157172410 @default.
• W3144318137 cites W2276054845 @default.
• W3144318137 cites W2314203153 @default.
• W3144318137 cites W2408394219 @default.
• W3144318137 cites W2411164536 @default.
• W3144318137 cites W2426176519 @default.
• W3144318137 cites W2464385197 @default.
• W3144318137 cites W2471418206 @default.
• W3144318137 cites W2472468653 @default.
• W3144318137 cites W2923226075 @default.
• W3144318137 cites W94842645 @default.
• W3144318137 cites W2071824398 @default.
• W3144318137 cites W2474334615 @default.
• W3144318137 hasPublicationYear "1997" @default.
• W3144318137 type Work @default.
• W3144318137 sameAs 3144318137 @default.
• W3144318137 citedByCount "0" @default.
• W3144318137 crossrefType "journal-article" @default.
• W3144318137 hasAuthorship W3144318137A5001230229 @default.
• W3144318137 hasAuthorship W3144318137A5084071486 @default.
• W3144318137 hasAuthorship W3144318137A5086484883 @default.
• W3144318137 hasConcept C121608353 @default.
• W3144318137 hasConcept C126322002 @default.
• W3144318137 hasConcept C142724271 @default.
• W3144318137 hasConcept C204232928 @default.
• W3144318137 hasConcept C2776231280 @default.
• W3144318137 hasConcept C2777546739 @default.
• W3144318137 hasConcept C2778778583 @default.
• W3144318137 hasConcept C2779013556 @default.
• W3144318137 hasConcept C52124034 @default.
• W3144318137 hasConcept C526805850 @default.
• W3144318137 hasConcept C59822182 @default.
• W3144318137 hasConcept C71924100 @default.
• W3144318137 hasConcept C86803240 @default.
• W3144318137 hasConcept C96232424 @default.
• W3144318137 hasConceptScore W3144318137C121608353 @default.
• W3144318137 hasConceptScore W3144318137C126322002 @default.
• W3144318137 hasConceptScore W3144318137C142724271 @default.
• W3144318137 hasConceptScore W3144318137C204232928 @default.
• W3144318137 hasConceptScore W3144318137C2776231280 @default.
• W3144318137 hasConceptScore W3144318137C2777546739 @default.

• next