FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144328695> ?p ?o ?g. }

• W3144328695 abstract "In our previous study, Human Signal Transduc- tion in Cancer Gene Array was used in 12 fresh tumor samples to detect the gene expression profiles in the esoph- ageal squamous cell carcinoma (ESCC) tissues matched adjacent non-cancerous samples. Among genes up-regulated at least twofold, b-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 were found. So subsequently, the aim of this study was to investigate the prognosis and clinicopathologic roles of b-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 in ESCC tissue. The mRNA and protein expression levels of b-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 genes in 70 ESCC and adjacent non-cancerous paraffin-embedded samples were determined by Real-Time Quantitative PCR (RT-PCR) and immunohistochemical staining. The mRNA expression level of b-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 in ESCC was significantly higher than that in the adjacent non-cancerous tissues (0.0821 ± 0.0416 vs. 0.0185 ± 0.0201, P = 0.0000; 1.9934 ± 1.9888 vs. 0.8863 ± 0.665, P = 0.0184; 0.0298 ± 0.0215 vs. 0.0189 ± 0.0187, P = 0.0017; 2.098 ± 0.091 vs. 1.016 ± 0.078, P = 0.0000; 2.181 ± 2.158 vs. 0.931 ± 0.894, P = 0.0152; respectively), and the protein expression level of determined genes was also significantly higher than that in the adjacent non-cancerous tissues (0.2835 ± 0.0844 vs. 0.2352 ± 0.0670, P = 0.0003; 0.3830 ± 0.0947 vs. 0.2721 ± 0.1474, P = 0.0000; 0.2637 ± 0.0348 vs. 0.2042 ± 0.0180, P = 0.0000; 0.2058 ± 0.0316 vs. 0.1218 ± 0.0518, P = 0.0000; 0.2736 ± 0.0834 vs. 0.2251 ± 0.0571, P = 0.0001; respectively). Then, the overexpression of mRNA and protein levels of b-catenin, Wnt1 and Bmi-1 was aggressively associated with lymph node metastasis, advanced pathological stage, and prognosis of the patients with ESCC (P 0.05). The up-expression of Hoxa9 mRNA and protein was also aggressively associated with lymph node metastasis and advanced pathological stage (P 0.05); however, the overexpression of Hoxa9 protein was not associated with the prognosis (P ( 0.05). Meanwhile, the hypo-expression of Smad4 mRNA was aggressively asso- ciated with advanced pathological stage and prognosis of the patients with ESCC (P 0.05); however, the hypo-expres- sion of Smad4 protein was neutral to the prognosis and lymph node metastasis (P ( 0.05). b-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 protein expression analysis showed that the positive outcomes of the combined detection of Wnt1 and b-catenin expression or Wnt1, b-catenin and Bmi-1 expression were significantly worse than those of a single target protein expression (P 0.05). Meantime, the prog- nosis of the combined positive expression of Wnt1, b-cate- nin, and Bmi-1 was poorer than that in the combined positive expression of Wnt1 and b-catenin (P 0.05). The prognosis of ESCC patients with the overexpression of Wnt1/b-catenin and Bmi-1 was relatively poor, and the level of Wnt1/ b-catenin and Bmi-1 was conversely correlated with advanced pathological stage and lymph node metastasis. The expression level of Smad4 and Hoxa9 mRNA was also associated with the prognosis of the patients with ESCC, pathological stage, and lymph node metastasis; however, they might not be the independent prognostic factor." @default.
• W3144328695 created "2021-04-13" @default.
• W3144328695 creator A5052848211 @default.
• W3144328695 creator A5062157156 @default.
• W3144328695 date "2012-01-01" @default.
• W3144328695 modified "2023-09-27" @default.
• W3144328695 title "Association of b-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 with the prognosis of esophageal squamous cell carcinoma" @default.
• W3144328695 cites W1481473039 @default.
• W3144328695 cites W1527340722 @default.
• W3144328695 cites W1939041072 @default.
• W3144328695 cites W1980115344 @default.
• W3144328695 cites W1980948407 @default.
• W3144328695 cites W1986022997 @default.
• W3144328695 cites W1990521388 @default.
• W3144328695 cites W1994262602 @default.
• W3144328695 cites W2002030118 @default.
• W3144328695 cites W2016291097 @default.
• W3144328695 cites W2016878020 @default.
• W3144328695 cites W2016962985 @default.
• W3144328695 cites W2029434623 @default.
• W3144328695 cites W2049216710 @default.
• W3144328695 cites W2050388756 @default.
• W3144328695 cites W2053479183 @default.
• W3144328695 cites W2054725891 @default.
• W3144328695 cites W2056782519 @default.
• W3144328695 cites W2059198036 @default.
• W3144328695 cites W2095452565 @default.
• W3144328695 cites W2097689792 @default.
• W3144328695 cites W2106368852 @default.
• W3144328695 cites W2119780609 @default.
• W3144328695 cites W2154871036 @default.
• W3144328695 cites W2400350205 @default.
• W3144328695 cites W2407399555 @default.
• W3144328695 cites W2615937932 @default.
• W3144328695 hasPublicationYear "2012" @default.
• W3144328695 type Work @default.
• W3144328695 sameAs 3144328695 @default.
• W3144328695 citedByCount "0" @default.
• W3144328695 crossrefType "journal-article" @default.
• W3144328695 hasAuthorship W3144328695A5052848211 @default.
• W3144328695 hasAuthorship W3144328695A5062157156 @default.
• W3144328695 hasConcept C104317684 @default.
• W3144328695 hasConcept C105580179 @default.
• W3144328695 hasConcept C121608353 @default.
• W3144328695 hasConcept C126322002 @default.
• W3144328695 hasConcept C137620995 @default.
• W3144328695 hasConcept C142724271 @default.
• W3144328695 hasConcept C143998085 @default.
• W3144328695 hasConcept C1491633281 @default.
• W3144328695 hasConcept C150194340 @default.
• W3144328695 hasConcept C204232928 @default.
• W3144328695 hasConcept C2994415158 @default.
• W3144328695 hasConcept C30145163 @default.
• W3144328695 hasConcept C3019992690 @default.
• W3144328695 hasConcept C48023723 @default.
• W3144328695 hasConcept C502942594 @default.
• W3144328695 hasConcept C54355233 @default.
• W3144328695 hasConcept C71924100 @default.
• W3144328695 hasConcept C86803240 @default.
• W3144328695 hasConceptScore W3144328695C104317684 @default.
• W3144328695 hasConceptScore W3144328695C105580179 @default.
• W3144328695 hasConceptScore W3144328695C121608353 @default.
• W3144328695 hasConceptScore W3144328695C126322002 @default.
• W3144328695 hasConceptScore W3144328695C137620995 @default.
• W3144328695 hasConceptScore W3144328695C142724271 @default.
• W3144328695 hasConceptScore W3144328695C143998085 @default.
• W3144328695 hasConceptScore W3144328695C1491633281 @default.
• W3144328695 hasConceptScore W3144328695C150194340 @default.
• W3144328695 hasConceptScore W3144328695C204232928 @default.
• W3144328695 hasConceptScore W3144328695C2994415158 @default.
• W3144328695 hasConceptScore W3144328695C30145163 @default.
• W3144328695 hasConceptScore W3144328695C3019992690 @default.
• W3144328695 hasConceptScore W3144328695C48023723 @default.
• W3144328695 hasConceptScore W3144328695C502942594 @default.
• W3144328695 hasConceptScore W3144328695C54355233 @default.
• W3144328695 hasConceptScore W3144328695C71924100 @default.
• W3144328695 hasConceptScore W3144328695C86803240 @default.
• W3144328695 hasLocation W31443286951 @default.
• W3144328695 hasOpenAccess W3144328695 @default.
• W3144328695 hasPrimaryLocation W31443286951 @default.
• W3144328695 hasRelatedWork W1973530948 @default.
• W3144328695 hasRelatedWork W1983592033 @default.
• W3144328695 hasRelatedWork W1999259859 @default.
• W3144328695 hasRelatedWork W2152752097 @default.
• W3144328695 hasRelatedWork W2157319858 @default.
• W3144328695 hasRelatedWork W2358242887 @default.
• W3144328695 hasRelatedWork W2361688476 @default.
• W3144328695 hasRelatedWork W2363187165 @default.
• W3144328695 hasRelatedWork W2369473237 @default.
• W3144328695 hasRelatedWork W2389958994 @default.
• W3144328695 hasRelatedWork W2398904413 @default.
• W3144328695 hasRelatedWork W2403945866 @default.
• W3144328695 hasRelatedWork W2416739355 @default.
• W3144328695 hasRelatedWork W2589518642 @default.
• W3144328695 hasRelatedWork W3028901750 @default.
• W3144328695 hasRelatedWork W3029494558 @default.
• W3144328695 hasRelatedWork W3029897466 @default.
• W3144328695 hasRelatedWork W3031673530 @default.
• W3144328695 hasRelatedWork W2011996448 @default.
• W3144328695 hasRelatedWork W2186627362 @default.

• next