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- W3144399622 endingPage "359" @default.
- W3144399622 startingPage "359" @default.
- W3144399622 abstract "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity." @default.
- W3144399622 created "2021-04-13" @default.
- W3144399622 creator A5019745875 @default.
- W3144399622 creator A5025735042 @default.
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- W3144399622 creator A5061223156 @default.
- W3144399622 creator A5061928130 @default.
- W3144399622 creator A5087825676 @default.
- W3144399622 date "2021-03-31" @default.
- W3144399622 modified "2023-10-06" @default.
- W3144399622 title "Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy" @default.
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