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- W3144422926 abstract "Objective To study the expressions of NLRP3 inflammasome and its downstream molecules in the gastric tissues and sera of Helicobacter pylori( H. pylori)-infected C57BL /6 mice,and to preliminary explore the role of NLRP3 inflammasome signalling pathway in the pathogenesis of H. pylori infection. Methods C57BL /6 mice were randomly divided into H. pylori infection group and PBS control group,and mice were sacrificed at different time points after H. pylori infection. The mRNA expressions of NLRP3 inflammasome and downstream signalling pathway related molecules in mouse gastric tissues were detected by RT-PCR,and the protein level of caspase-1 was analyzed by Western blotting. The contents of IL-1β,IL-18 and IL-33 in the sera were measured with ELISA. Results Chronic inflammatory response was observed in the gastric mucosal tissues of H. pylori-infected mice and it gradually aggravated. Compared with the control mice,the mRNA expressions of NLRP3 inflammasome signalling pathway related molecules and the protein level of caspase-1 increased markedly in the gastric tissues of H. pylori-infected mice. Moreover,the contents of IL-1β,IL-18 and IL-33 in the sera of H. pylori-infected mice were also significantly elevated. Conclusion NLRP3 inflammasome signalling pathway could be activated by H. pylori infection." @default.
- W3144422926 created "2021-04-13" @default.
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- W3144422926 date "2013-01-01" @default.
- W3144422926 modified "2023-09-24" @default.
- W3144422926 title "The expressions of NLRP3 inflammasome and its downstream molecules in the mouse model of Helicobacter pylori infection" @default.
- W3144422926 hasPublicationYear "2013" @default.
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