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- W3144466682 endingPage "63" @default.
- W3144466682 startingPage "45" @default.
- W3144466682 abstract "It is estimated that 10% of carbon throughout the cosmos is in the form of carbon monoxide (CO). Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric oxide (NO), and hydrogen sulfide (H2S), for which all of life has co-evolved with. The history of CO can be loosely traced to mythological and prehistoric origins with rudimentary understanding emerging in the middle ages. Ancient literature is focused on CO's deadly toxicity which is understandable in the context of our primitive relationship with coal and fire. Scientific inquiry into CO appears to have emerged throughout the 1700s followed by chemical and toxicological profiling throughout the 1800s. Despite CO's ghastly reputation, several of the 18th and 19th century scientists suggested a therapeutic application of CO. Since 2000, the fundamental understanding of CO as a deadly nuisance has undergone a paradigm shift such that CO is now recognized as a neurotransmitter and viable pharmaceutical candidate. This review is intended to provide a brief history on the trace origins pertaining to endogenous formation and therapeutic application of CO." @default.
- W3144466682 created "2021-04-13" @default.
- W3144466682 creator A5036713702 @default.
- W3144466682 creator A5050663577 @default.
- W3144466682 creator A5060717397 @default.
- W3144466682 creator A5074584860 @default.
- W3144466682 date "2021-06-01" @default.
- W3144466682 modified "2023-09-26" @default.
- W3144466682 title "A brief history of carbon monoxide and its therapeutic origins" @default.
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