Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144473185> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- W3144473185 abstract "We appreciate Dr. Brennan and colleagues’ novel observation that shedding of urinary tract JC polyomavirus (JCV) associates with reduced rates of acute renal allograft rejection.1 Bacterial urinary tract infections trigger acute rejection and non-JC viral infections may do the same. This finding further supports protective effects of urinary tract JCV on CKD and APOL1 gene-JCV interactions reducing risk of non-diabetic nephropathy.2;3 These diverse clinical scenarios suggest that JCV exhibits a commensal relationship with urothelial and kidney cells. JC viruria is not likely indicative of true infection, but colonization. This is akin to protective GI tract bacteria that inhibit growth of pathologic strains. As such, asymptomatic urinary tract JCV shedding could reflect health. Absent JCV, pathologic viruses may infect urothelial cells, ascend to and infect kidney cells, and cause chronic renal dysfunction or acute rejection. All studies support that a single urothelial viral strain inhibits growth of others.1–3 Relative to the GI tract, the urine virome remains understudied. Known and novel viruses may reside in the urinary tract and be readily detectable in urine. Next generation sequencing in urine could identify intruding viruses that “move into the neighborhood when JCV is away”.4 Pathogenic viruses might underlie gene-virus interactions, CKD, and acute rejection. Kidney disease and acute rejection therapies may emerge from identification of these unwelcome guests.Barry I. Freedman, MDJasmin Divers, PhDKevin P. High, MD" @default.
- W3144473185 created "2021-04-13" @default.
- W3144473185 creator A5035175377 @default.
- W3144473185 creator A5059128990 @default.
- W3144473185 creator A5087036525 @default.
- W3144473185 date "2014-05-01" @default.
- W3144473185 modified "2023-10-18" @default.
- W3144473185 title "The authors reply:." @default.
- W3144473185 cites W1588441834 @default.
- W3144473185 cites W1968718127 @default.
- W3144473185 cites W2023694860 @default.
- W3144473185 cites W2163631211 @default.
- W3144473185 doi "https://doi.org/10.1038/ki.2014.40" @default.
- W3144473185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143177" @default.
- W3144473185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24786886" @default.
- W3144473185 hasPublicationYear "2014" @default.
- W3144473185 type Work @default.
- W3144473185 sameAs 3144473185 @default.
- W3144473185 citedByCount "1" @default.
- W3144473185 countsByYear W31444731852019 @default.
- W3144473185 crossrefType "posted-content" @default.
- W3144473185 hasAuthorship W3144473185A5035175377 @default.
- W3144473185 hasAuthorship W3144473185A5059128990 @default.
- W3144473185 hasAuthorship W3144473185A5087036525 @default.
- W3144473185 hasBestOaLocation W31444731851 @default.
- W3144473185 hasConcept C71924100 @default.
- W3144473185 hasConceptScore W3144473185C71924100 @default.
- W3144473185 hasLocation W31444731851 @default.
- W3144473185 hasLocation W31444731852 @default.
- W3144473185 hasOpenAccess W3144473185 @default.
- W3144473185 hasPrimaryLocation W31444731851 @default.
- W3144473185 hasRelatedWork W1489783725 @default.
- W3144473185 hasRelatedWork W1506200166 @default.
- W3144473185 hasRelatedWork W2039318446 @default.
- W3144473185 hasRelatedWork W2048182022 @default.
- W3144473185 hasRelatedWork W2080531066 @default.
- W3144473185 hasRelatedWork W2604872355 @default.
- W3144473185 hasRelatedWork W2748952813 @default.
- W3144473185 hasRelatedWork W2899084033 @default.
- W3144473185 hasRelatedWork W3032375762 @default.
- W3144473185 hasRelatedWork W3108674512 @default.
- W3144473185 isParatext "false" @default.
- W3144473185 isRetracted "false" @default.
- W3144473185 magId "3144473185" @default.
- W3144473185 workType "article" @default.