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- W3144487059 abstract "Aim:To determine the Ca~(2+)source and cellular mechanisms of spontaneous Ca~(2+) oscillations in hippocampal astrocytes.Methods:The cultured cells were loaded with Fluo-4 AM,the indicator of intracellular Ca~(2+),and the dynamic Ca~(2+)tran- sients were visualized with confocal laser-scanning microscopy.Results:The spontaneous Ca~(2+)oscillations in astrocytes were observed first in co-cultured hippocampal neurons and astrocytes.These oscillations were not affected by tetrodotoxin(TTX)treatment and kept up in purity cultured astrocytes.The spontaneous Ca~(2+)oscillations were not impacted after blocking the voltage-gated Ca~(2+)channels or ethylenediamine tetraacetic acid(EDTA)bathing,indicating that intracellular Ca~(2+)elevation was not the result of extracellular Ca~(2+)influx. Furthermore,the correlation between the spontaneous Ca~(2+)oscillations and the Ca~(2+)store in endoplasmic reticulum(ER)were investigated with pharmacological experiments.The oscillations were:1)enhanced when cells were exposed to both low Na~+(70 mmol/L)and high Ca~(2+)(5 mmol/L)solution,and eliminated completely by 2 μmol/L thapsigargin,a blocker of sarcoplasmic reticulum Ca~(2+)-ATPase;and 2)still robust alter the application with either 50μmol/L ryanodine or 400μmol/L tetracaine,two specific antagonists of ryanodine receptors,but depressed in a dose-dependent manner by 2-APB,an InsP_3 receptors(InsP_3R)blocker. Conclusion:InsP_3R-induced ER Ca~(2+)release is an important cellular mechanism for the initiation of spontaneous Ca~(2+)oscillation in hippocampal astrocytes." @default.
- W3144487059 created "2021-04-13" @default.
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- W3144487059 date "2006-01-01" @default.
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- W3144487059 title "Cellular mechanism for spontaneous calcium oscillations in astrocytes" @default.
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