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• W3144520478 abstract "WASP homolog associated with actin, mem- branes and microtubules (WHAMM) is a newly discovered nucleation-promoting factor that links actin and microtu- bule cytoskeleton and regulates transport from the endo- plasmic reticulum to the Golgi apparatus. However, knowledge of WHAMM is limited to interphase somatic cells. In this study, we examined its localization and function in mouse oocytes during meiosis. Immunostaining showed that in the germinal vesicle (GV) stage, there was no WHAMM signal; after meiosis resumption, WHAMM was associated with the spindle at prometaphase I (Pro MI), metaphase I (MI), telophase I (TI) and metaphase II (MII) stages. Nocodazole and taxol treatments showed that WHAMM was localized around the MI spindle. Depletion of WHAMM by microinjection of specific short interfering (si)RNA into the oocyte cytoplasm resulted in failure of spindle migration, disruption of asymmetric cytokinesis and a decrease in the first polar body extrusion rate during meiotic maturation. Moreover, actin cap formation was also disrupted after WHAMM depletion, confirming the failure of spindle migration. Taken together, our data suggest that WHAMM is required for peripheral spindle migration and asymmetric cytokinesis during mouse oocyte maturation." @default.
• W3144520478 created "2021-04-13" @default.
• W3144520478 creator A5076984250 @default.
• W3144520478 date "2013-01-01" @default.
• W3144520478 modified "2023-09-27" @default.
• W3144520478 title "WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes" @default.
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• W3144520478 hasPublicationYear "2013" @default.
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