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- W3144547187 abstract "不对称的 dimethylarginine (ADMA ) 是氮的氧化物 synthase (NOS ) 的一个内长的禁止者，它能是由 dimethylarginine-dimethylaminohydrolase (DDAH ) 的 hydrolyzed。adipocytes 能生产 DDAH/ADMA，这被报导了，但是它的角色仍然保持未知。在现在的学习， weexamined 胰岛素敏感使用上的导出 adipocyte 的 DDAH/ADMA 的效果动物和细胞模型。结果显示出 thatin 高肥的喂食谱的糖尿病的老鼠的脂肪质的织物，以及在高葡萄糖( 25 公里)，正胰岛素( 100 nM )对待 3T3-L1adipocytes ，胰岛素受体 substance-1 ( IRS-1 )的表示层次，葡萄糖 transporter-4 ( GLUT-4 )，并且 DDAH isoform-2 ( DDAH-2 )与控制相比是下面调整的，尽管 DDAH-1 表示没显示出重要变化。我们也观察到氮的氧化物 bioavailability， DDAH 和 NOS 活动 weresubsequently 减少了，当本地 ADMA 内容在糖尿病的脂肪质的织物被提高时。进高对待葡萄糖、对待胰岛素的 3T3-L1 adipocytes 的人的 DDAH-2 基因的 Transfection 显著地改善了 DDAH 活动，减少的 ADMA 内容，并且起来调整 IRS-1 和 GLUT-4 的 mRNA 表示层次。这些调查结果建议在类型 2 糖尿病 mellitus 的发展，在 adipocytes 的本地 DDAH-2 可能在调整胰岛素敏感玩 importantrole。" @default.
- W3144547187 created "2021-04-13" @default.
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- W3144547187 date "2013-01-01" @default.
- W3144547187 modified "2023-09-26" @default.
- W3144547187 title "The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus" @default.
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