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- W3144561808 abstract "Human c-myc cDNA was fused with the hormonebinding domain (HBD) cDNA of murine estrogen receptorgene and the chimeric gene was introduced into the CHOcells. The fusion protein, c-MycER, becomes activatedwhen the synthetic steroid, 4-hydroxy-tamoxifen (OHT),binds HBD. Activated c-MycER, likely c-Myc, can inducequiescent CHO cells reentry into S phase and subsequentcell death under serum-free condition. In addition, theexpression of some proposed c-myc target genes such asODC, MrDb, cad, rcc1 and rc1 were found to increase uponOHT induction before S, phase entry and apoptosis, indicating that these target genes are involved in cell cycleregulation and/or apoptosis control. However, the mutantD106-143c-MycER protein does not have above activities." @default.
- W3144561808 created "2021-04-13" @default.
- W3144561808 creator A5060135607 @default.
- W3144561808 date "1999-01-01" @default.
- W3144561808 modified "2023-09-23" @default.
- W3144561808 title "Deregulated c-myc expression in quiescent CHO cellsinduces target gene transcription and subsequent apoptotic phenotype" @default.
- W3144561808 hasPublicationYear "1999" @default.
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