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- W3144594749 abstract "Our purpose was to assess the influence of liver steatosis on diffusion by triexponential analysis. Thirty- three patients underwent diffusion-weighted magnetic res- onance imaging with multiple b values for perfusion-rela- ted diffusion, fast free diffusion, and slow restricted diffusion coefficients (Dp, Df, Ds) and fractions (Fp, Ff, Fs). They also underwent dual-echo gradient-echo imaging for measurement of the hepatic fat fraction (HFF). Of these, 13 patients were included in the control group and 20 in the fatty liver group with HFF (5 %. The parameters of the two groups were compared by use of the Mann-Whitney U test. The relationships between diffusion coefficients and HFFs were assessed by use of the Pearson correlation. Dp and Df were reduced significantly in the steatotic liver group compared with those in the control group (Dp = 27.72 ± 6.61 9 10 -3 vs. 33.33 ± 6.47 9 10 -3 mm 2 /s, P = 0.0072; Df = 1.70 ± 0.53 9 10 -3 vs. 2.06 ± 0.40 9 10 -3 mm 2 /s, P = 0.0224). There were no significant differences in the other parameters between the two groups. Furthermore, Dp and Df were correlated with HFF (P 0.0001, r =- 0.64 and P = 0.0008, r =- 0.56, respectively). Decreased liver perfusion in steatosis caused the reduction in Dp, and extracellular fat accumulation and intracellular fat droplets in steatosis led to the reduction in Df. Thus, the influence of hepatic steatosis should be taken into consideration when triexponential function analysis is used for assessment of diffuse liver disease." @default.
- W3144594749 created "2021-04-13" @default.
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- W3144594749 date "2014-01-01" @default.
- W3144594749 modified "2023-09-26" @default.
- W3144594749 title "Diffusion analysis with triexponential function in hepatic steatosis" @default.
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