FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144620728> ?p ?o ?g. }

• W3144620728 endingPage "113430" @default.
• W3144620728 startingPage "113430" @default.
• W3144620728 abstract "Metastasis is the main cause of death in cancer patients; therefore, new strategies or technologies that can inhibit the growth of primary tumors and their metastatic spread are extremely valuable. In this study, we selected an E-selectin-binding peptide as a targeting ligand and an inhibitor of metastasis, and conjugated this peptide with SN38 and PEG to produce an amphiphilic PEGylated peptide-drug conjugate (PDC). Novel self-assembled nanoparticles were then formed by the amphiphilic conjugate. The particles were actively targeted to the tumor vasculature by the peptide and passively to the tumor site by the enhanced permeability and retention (EPR) effect. As a nano-prodrug, this multifunctional conjugate (PEG-Pep-SN38) could reduce tumor growth, with an effect similar to that of irinotecan. Moreover, it could prolong the survival of mice bearing primary HCT116 tumors, which was not observed for its parent drug, SN38, nor the clinical prodrug of SN38 (irinotecan). Furthermore, this PDC prodrug prevented B16–F10 colonization in the lungs of mice. This study describes a new tumor vasculature-targeting PDC nano-prodrug with convenient preparation and high potential for cancer therapy, with the potential to be applied to other chemotherapeutic drugs." @default.
• W3144620728 created "2021-04-13" @default.
• W3144620728 creator A5021353327 @default.
• W3144620728 creator A5033077746 @default.
• W3144620728 creator A5045261459 @default.
• W3144620728 creator A5047191802 @default.
• W3144620728 creator A5055257887 @default.
• W3144620728 creator A5058479146 @default.
• W3144620728 creator A5060165452 @default.
• W3144620728 creator A5067274838 @default.
• W3144620728 creator A5078364103 @default.
• W3144620728 creator A5083296343 @default.
• W3144620728 creator A5089019392 @default.
• W3144620728 creator A5090006212 @default.
• W3144620728 date "2021-07-01" @default.
• W3144620728 modified "2023-09-29" @default.
• W3144620728 title "Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis" @default.
• W3144620728 cites W1507777757 @default.
• W3144620728 cites W1560897669 @default.
• W3144620728 cites W1607665397 @default.
• W3144620728 cites W18052831 @default.
• W3144620728 cites W1965001670 @default.
• W3144620728 cites W2013308107 @default.
• W3144620728 cites W2019042150 @default.
• W3144620728 cites W2021548785 @default.
• W3144620728 cites W2022233074 @default.
• W3144620728 cites W2022837147 @default.
• W3144620728 cites W2033186975 @default.
• W3144620728 cites W2034982045 @default.
• W3144620728 cites W2046851174 @default.
• W3144620728 cites W2084329943 @default.
• W3144620728 cites W2089370460 @default.
• W3144620728 cites W2089435825 @default.
• W3144620728 cites W2095412415 @default.
• W3144620728 cites W2095554214 @default.
• W3144620728 cites W2136226205 @default.
• W3144620728 cites W2141711104 @default.
• W3144620728 cites W2157453847 @default.
• W3144620728 cites W2298229328 @default.
• W3144620728 cites W2910740907 @default.
• W3144620728 cites W2916429698 @default.
• W3144620728 cites W3063903513 @default.
• W3144620728 cites W3174104277 @default.
• W3144620728 doi "https://doi.org/10.1016/j.ejmech.2021.113430" @default.
• W3144620728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33865152" @default.
• W3144620728 hasPublicationYear "2021" @default.
• W3144620728 type Work @default.
• W3144620728 sameAs 3144620728 @default.
• W3144620728 citedByCount "11" @default.
• W3144620728 countsByYear W31446207282021 @default.
• W3144620728 countsByYear W31446207282022 @default.
• W3144620728 countsByYear W31446207282023 @default.
• W3144620728 crossrefType "journal-article" @default.
• W3144620728 hasAuthorship W3144620728A5021353327 @default.
• W3144620728 hasAuthorship W3144620728A5033077746 @default.
• W3144620728 hasAuthorship W3144620728A5045261459 @default.
• W3144620728 hasAuthorship W3144620728A5047191802 @default.
• W3144620728 hasAuthorship W3144620728A5055257887 @default.
• W3144620728 hasAuthorship W3144620728A5058479146 @default.
• W3144620728 hasAuthorship W3144620728A5060165452 @default.
• W3144620728 hasAuthorship W3144620728A5067274838 @default.
• W3144620728 hasAuthorship W3144620728A5078364103 @default.
• W3144620728 hasAuthorship W3144620728A5083296343 @default.
• W3144620728 hasAuthorship W3144620728A5089019392 @default.
• W3144620728 hasAuthorship W3144620728A5090006212 @default.
• W3144620728 hasConcept C108215921 @default.
• W3144620728 hasConcept C121608353 @default.
• W3144620728 hasConcept C126322002 @default.
• W3144620728 hasConcept C134306372 @default.
• W3144620728 hasConcept C178790620 @default.
• W3144620728 hasConcept C185592680 @default.
• W3144620728 hasConcept C197336794 @default.
• W3144620728 hasConcept C2776694085 @default.
• W3144620728 hasConcept C2779013556 @default.
• W3144620728 hasConcept C2779281246 @default.
• W3144620728 hasConcept C2779820397 @default.
• W3144620728 hasConcept C2780035454 @default.
• W3144620728 hasConcept C2780259306 @default.
• W3144620728 hasConcept C33923547 @default.
• W3144620728 hasConcept C502942594 @default.
• W3144620728 hasConcept C526805850 @default.
• W3144620728 hasConcept C55493867 @default.
• W3144620728 hasConcept C71924100 @default.
• W3144620728 hasConcept C98274493 @default.
• W3144620728 hasConceptScore W3144620728C108215921 @default.
• W3144620728 hasConceptScore W3144620728C121608353 @default.
• W3144620728 hasConceptScore W3144620728C126322002 @default.
• W3144620728 hasConceptScore W3144620728C134306372 @default.
• W3144620728 hasConceptScore W3144620728C178790620 @default.
• W3144620728 hasConceptScore W3144620728C185592680 @default.
• W3144620728 hasConceptScore W3144620728C197336794 @default.
• W3144620728 hasConceptScore W3144620728C2776694085 @default.
• W3144620728 hasConceptScore W3144620728C2779013556 @default.
• W3144620728 hasConceptScore W3144620728C2779281246 @default.
• W3144620728 hasConceptScore W3144620728C2779820397 @default.
• W3144620728 hasConceptScore W3144620728C2780035454 @default.
• W3144620728 hasConceptScore W3144620728C2780259306 @default.
• W3144620728 hasConceptScore W3144620728C33923547 @default.

• next