Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144623496> ?p ?o ?g. }
- W3144623496 endingPage "1743" @default.
- W3144623496 startingPage "1743" @default.
- W3144623496 abstract "Despite multimodal treatment, survival chances for high-risk neuroblastoma patients remain poor. Immunotherapeutic approaches focusing on the activation and/or modification of host immunity for eliminating tumor cells, such as chimeric antigen receptor (CAR) T cells, are currently in development, however clinical trials have failed to reproduce the preclinical results. The tumor microenvironment is emerging as a major contributor to immune suppression and tumor evasion in solid cancers and thus has to be overcome for therapies relying on a functional immune response. Among the cellular components of the neuroblastoma tumor microenvironment, suppressive myeloid cells have been described as key players in inhibition of antitumor immune responses and have been shown to positively correlate with more aggressive disease, resistance to treatments, and overall poor prognosis. This review article summarizes how neuroblastoma-driven inflammation induces suppressive myeloid cells in the tumor microenvironment and how they in turn sustain the tumor niche through suppressor functions, such as nutrient depletion and generation of oxidative stress. Numerous preclinical studies have suggested a range of drug and cellular therapy approaches to overcome myeloid-derived suppression in neuroblastoma that warrant evaluation in future clinical studies." @default.
- W3144623496 created "2021-04-13" @default.
- W3144623496 creator A5002067954 @default.
- W3144623496 creator A5021450101 @default.
- W3144623496 creator A5028660772 @default.
- W3144623496 date "2021-04-06" @default.
- W3144623496 modified "2023-09-30" @default.
- W3144623496 title "Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment" @default.
- W3144623496 cites W1496109170 @default.
- W3144623496 cites W1566335138 @default.
- W3144623496 cites W1641611552 @default.
- W3144623496 cites W1864128415 @default.
- W3144623496 cites W1925817305 @default.
- W3144623496 cites W1933912253 @default.
- W3144623496 cites W1971195317 @default.
- W3144623496 cites W1971426748 @default.
- W3144623496 cites W1975344029 @default.
- W3144623496 cites W1977179270 @default.
- W3144623496 cites W1978704906 @default.
- W3144623496 cites W1980485314 @default.
- W3144623496 cites W1980638418 @default.
- W3144623496 cites W1993262247 @default.
- W3144623496 cites W1993340690 @default.
- W3144623496 cites W1993677761 @default.
- W3144623496 cites W2000725338 @default.
- W3144623496 cites W2004150448 @default.
- W3144623496 cites W2011210685 @default.
- W3144623496 cites W2012405690 @default.
- W3144623496 cites W2013869536 @default.
- W3144623496 cites W2019209583 @default.
- W3144623496 cites W2021268612 @default.
- W3144623496 cites W2021956054 @default.
- W3144623496 cites W2026861011 @default.
- W3144623496 cites W2033927066 @default.
- W3144623496 cites W2035110681 @default.
- W3144623496 cites W2037313669 @default.
- W3144623496 cites W2038974826 @default.
- W3144623496 cites W2039146285 @default.
- W3144623496 cites W2046768931 @default.
- W3144623496 cites W2048434210 @default.
- W3144623496 cites W2052253338 @default.
- W3144623496 cites W2054472394 @default.
- W3144623496 cites W2057848975 @default.
- W3144623496 cites W2059492353 @default.
- W3144623496 cites W2060672294 @default.
- W3144623496 cites W2060727628 @default.
- W3144623496 cites W2061123122 @default.
- W3144623496 cites W2062873927 @default.
- W3144623496 cites W2064510700 @default.
- W3144623496 cites W2065210647 @default.
- W3144623496 cites W2068793888 @default.
- W3144623496 cites W2070540560 @default.
- W3144623496 cites W2071959986 @default.
- W3144623496 cites W2073310925 @default.
- W3144623496 cites W2075671029 @default.
- W3144623496 cites W2076743146 @default.
- W3144623496 cites W2078150187 @default.
- W3144623496 cites W2080886891 @default.
- W3144623496 cites W2085478834 @default.
- W3144623496 cites W2093705034 @default.
- W3144623496 cites W2095746947 @default.
- W3144623496 cites W2096616470 @default.
- W3144623496 cites W2102332546 @default.
- W3144623496 cites W2104901632 @default.
- W3144623496 cites W2107130188 @default.
- W3144623496 cites W2111463022 @default.
- W3144623496 cites W2114444869 @default.
- W3144623496 cites W2115369099 @default.
- W3144623496 cites W2118980621 @default.
- W3144623496 cites W2120539661 @default.
- W3144623496 cites W2120849621 @default.
- W3144623496 cites W2128957395 @default.
- W3144623496 cites W2132719717 @default.
- W3144623496 cites W2134338732 @default.
- W3144623496 cites W2140022207 @default.
- W3144623496 cites W2149360266 @default.
- W3144623496 cites W2152887115 @default.
- W3144623496 cites W2153232526 @default.
- W3144623496 cites W2155056321 @default.
- W3144623496 cites W2156978579 @default.
- W3144623496 cites W2158795833 @default.
- W3144623496 cites W2162085901 @default.
- W3144623496 cites W2163494047 @default.
- W3144623496 cites W2165064029 @default.
- W3144623496 cites W2180958882 @default.
- W3144623496 cites W2324555285 @default.
- W3144623496 cites W2400276917 @default.
- W3144623496 cites W2470333723 @default.
- W3144623496 cites W2471500324 @default.
- W3144623496 cites W2472901304 @default.
- W3144623496 cites W2488076079 @default.
- W3144623496 cites W2531693716 @default.
- W3144623496 cites W2541478996 @default.
- W3144623496 cites W2560292102 @default.
- W3144623496 cites W2560781164 @default.
- W3144623496 cites W2561408014 @default.
- W3144623496 cites W2582686270 @default.
- W3144623496 cites W2584822160 @default.