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• W3144655904 abstract "Background: Although the prevalence of Helicobacter pylori infection in Indonesia has been investigated, it is controversial and primarily investigated Javanese populations.We examined the prevalence of H. pylori infection using four different tests in five largest islands in Indonesia. We also analyzed virulence factors and population genetics. We hypothesized that the low prevalence ofH. pylori infection, characterized of virulence factors and population genetics contributes to the low incidence of gastric cancer in Indonesia. Methods: A total 245 subjects with dyspeptic symptoms from Jakarta and Surabaya (Java island), Medan (Sumatera Island), Pontianak (Borneo Island), Makassar (Celebes island) and Yowari (Papua Island) were included in this study. The status of H. pylori infection was based on culture, histology, immunohistochemistry and rapid urease test. Histological scores were evaluated according to the Update Sydney System and the Operative Link for Gastritis Assessment (OLGA) system. The genotypes of virulence factors and multilocus sequence typing (MLST) using seven housekeeping genes were examined by polymerase chain reaction (PCR) and DNA sequencing. In some isolated strains, whole-genome sequencing was also performed using the next generation sequencer. Results:We confirmed that low prevalence of H. pylori infection in Indonesia (15.9%). Papua and Makassar ethnics have higher risk for H. pylori infection than Javanese and Dayak ethnics (OR = 7.1 OR = 6.2 and OR = 7.40, OR = 6.49, respectively; P <0.05). Alcohol consumption had relation with the prevalence of H. pylori infection (OR = 6.8, P <0.05). H. pylori infection and ethnogeographic were associated with the severity outcome of histology. A total of 30 strains could be isolated and only one was cagA negative. East-Asian type cagA (46.6%), pre-EPIYA 18-bp deletion type (60.0%), vacA s1a (50.0%) and m1b (56.7%), dupA negative (93.3%), oipA off (53.3%), iceA1 positive/ iceA2 negative (56.7%) and double positive of jhp0562/β-(1,3)galT (50.0%) were predominant genotype in Indonesia. We also found high proportion of vacA m2 genotype (26.7%). Interestingly, Papua strains showed ABB type cagA and novel type of 0.7 kb middle region of vacA (m1d). MLST analysis using seven house keeping gene and whole genome revealed that Indonesian population were divided in to three spesific population type which have related with ethnogeographic region. Conclusions: The low incidence of gastric cancer in Indonesia could be attributed to the low prevalence of H. pylori infection, characteristic of virulence factors (high proportion of non East-Asia type cagA, vacA m2, dupA negative and oipA off) and population genetics." @default.
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• W3144655904 date "2015-01-01" @default.
• W3144655904 modified "2023-09-25" @default.
• W3144655904 title "Su1929 The Primary Resistance of Helicobacter pylori in Taiwan After the National Policy to Restrict Antibiotic Consumption and Its Relation to Virulence Factors - A Nationwide Study" @default.
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