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- W3144710039 abstract "Objective To detect the expression of β-arrestin 2 in CD4+T cells in acute asthmatic murine models as well as the effect of β-arrestin 2 on expression of T-bet.Methods Splenic CD4+T cells origining from asthmatic murine models were isolated by immunomagnetic bead separation.After β-arrestin 2 expression was knocked down by RNA interference,β-arrestin 2 as well as T-bet mRNA and protein expression were determined.Results siRNA-Arrb2-1123 had better silencing effect than other siRNA sequences.β-arrestin 2 expression in splenic CD4+T cells in asthmatic murine models was significantly higher than that of the normal group(P0.01).After β-arrestin 2 expression was knocked down by RNA interference,T-bet mRNA and protein expression in splenic CD4+T cells in asthmatic mice were significantly increased(P0.05).Conclusions β-arrestin 2 probably contributes to the pathogenesis of asthma by inhibiting T-bet expression in CD4+T cells." @default.
- W3144710039 created "2021-04-13" @default.
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- W3144710039 date "2011-01-01" @default.
- W3144710039 modified "2023-09-24" @default.
- W3144710039 title "Effect of β-arrestin 2 on T-bet expression of splenic CD4~+T cells in asthmatic murine model" @default.
- W3144710039 hasPublicationYear "2011" @default.
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