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- W3144714716 abstract "The regulation of gene networks that define hepatic metabolism is a complex but critical process that directs the in vivo disposition of xenobiotics and endogenous compounds, which often determines the toxic fate of chemical exposures. The constitutive androstane receptor (CAR; CAR1; NR1I3) is a member of the nuclear receptor superfamily that regulates expression of genes whose products act at all three phases of hepatic metabolism and transport including phase I monooxygenation, phase II conjugation, and phase III transporters that include multidrug resistance-associated proteins and organic anion transporting polypeptides. CAR is expressed primarily in the liver and intestinal enterocytes. An increasingly important role of CAR as a regulator of physiological processes has become apparent, in part due to the ability of the receptor to modulate the disposition of endogenous substances including bile acids, thyroid hormone, heme, and steroids. In addition, CAR activity impinges upon cholesterol homeostasis and signaling pathways that control food consumption. Thus, the biological and toxicological processes regulated by this receptor are integral to health. This chapter provides a brief history of the background and events leading to the discovery of CAR and reviews several of the functional attributes of the receptor in the context of its role as a key regulator with the nuclear receptor superfamily." @default.
- W3144714716 created "2021-04-13" @default.
- W3144714716 creator A5028135927 @default.
- W3144714716 creator A5032138287 @default.
- W3144714716 date "2010-01-01" @default.
- W3144714716 modified "2023-09-25" @default.
- W3144714716 title "Constitutive Androstane Receptor" @default.
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