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• W3144774954 abstract "• Sex-specific metabolic changes in COVID-19 plasma during the recovery process. • Metabolic activities are increased in COVID-19 patients after the cure. • Women have shorter length of hospitalization of COVID-19 infection than men. • Plasma metabolic profiling may predict the duration from positive to negative in non-severe COVID-19 patients. Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC–MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling." @default.
• W3144774954 created "2021-04-13" @default.
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• W3144774954 date "2021-01-01" @default.
• W3144774954 modified "2023-10-16" @default.
• W3144774954 title "Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process" @default.
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• W3144774954 doi "https://doi.org/10.1016/j.csbj.2021.03.039" @default.
• W3144774954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8021501" @default.
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• W3144774954 hasPublicationYear "2021" @default.
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