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- W3144788734 abstract "Objective To study the expression of angiopoietin-like protein 3(ANGPTL3) mRNA successively in kidney of adriamycin (ADR)-induced nephrotic rats during the development of proteinuria, and to disclose the possible assosiation of ANGPTL3 with proteinuria. Methods Adriamycininduced nephrotic rat models were established by a single injection of adriamycin via the tail vein. Glomeruli and cortex tubuli of rats were dissected by laser microdissection. Real time quantitative RT-PCR was used to study the expression of ANGPTL3mRNA in kidney of ADR rate at 7, 14, 21 and 28 days successively following adriamycin injection. Results (1) In ADR rats, urinary protein and the level of triglyceride and cholesterol in serum increased significantly at day 14 (P 0.01, 0.05 and 0.01, respectively), at same time, serum albumin decreased significantly (P0.01). Changes of these indices reached the peak level at day 28. (2) Glomeruli and cortex tubuli of rats were dissected successfully by laser microdissection. (3) The mRNA of ANGPTL3 in total cortex of kidney in ADR rat increased significantly at day 21 (P 0.01) and at day 28 (P 0.05) compared to that of control. (4) The tendency of ANGPTL3 mRNA expression in glomeruli of ADR rats was as the same as that in total cortex. ADR rats had a higher expression level of ANGPTL3mRNA in glomeruli at day 21 and day 28 compared to that of control (both P 0.05). (5) There was no significantly change of ANGPTL3 mRNA expression in cortex tubuli following adriamycin injection. Conclusions ANGPTL3 mRNA can be expressed in the kidneys of normal and ARD rats. The expression of ANGPTL3 mRNA increases in glomeruli of ADR rats during the development of proteinuria." @default.
- W3144788734 created "2021-04-13" @default.
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- W3144788734 date "2006-01-01" @default.
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- W3144788734 title "Expression of ANGPTL3 mRNA in kidney of adriamycin-induced nephrotic rats" @default.
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