FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144799488> ?p ?o ?g. }

• W3144799488 endingPage "102516" @default.
• W3144799488 startingPage "102516" @default.
• W3144799488 abstract "Glutamine (GLN) used as a dietary supplement is practically insoluble in water, which reduces its bioavailability after oral administration. Here, effervescent GLN (EBGLN) was prepared by comminution with an effervescent base (EB) that enhances its water solubility. EB (80 mg/mL) composed of citric acid, tartaric acid, and sodium bicarbonate was used in the ratio 1:2:3. This formulation was characterized in the liquid state (solubility studies, pH, effervescence time, GLN content) and solid-state (size analysis, residual moisture, flow properties studies, differential scanning calorimetry, thermogravimetric analysis, powder x-ray diffraction, and Fourier transformed infrared Raman spectroscopy). In vivo studies were performed with adult overnight fasted (15 h) rats. The rats were euthanized 30, 60, and 120 min after the oral administration (gavage) of water (vehicle of GLN), EB (vehicle of EBGLN), GLN (glutamine dissolved in water), or EBGLN (GLN dissolved in EB). Blood was collected and the plasma concentrations (nmol/mL) of GLN, glutamic acid, alanine, aspartic acid, asparagine, histidine, serine, arginine, tyrosine, tryptophan, methionine, phenylalanine, valine, leucine, and isoleucine were obtained by high-performance liquid chromatography (HPLC) analysis. Physicochemical characterizations indicated that EBGLN was present as a physical mixture with lower crystallinity and higher solubility when compared with pure GLN. In vivo experiments demonstrated improved oral GLN bioavailability from EBGLN (500 mg/kg - 30 min and 60 min). Therefore, the solid effervescent system represents a new strategy for oral glutamine delivery with potential clinical relevance." @default.
• W3144799488 created "2021-04-13" @default.
• W3144799488 creator A5003626587 @default.
• W3144799488 creator A5024261209 @default.
• W3144799488 creator A5050525574 @default.
• W3144799488 creator A5052090694 @default.
• W3144799488 creator A5052115473 @default.
• W3144799488 creator A5070576555 @default.
• W3144799488 creator A5083882147 @default.
• W3144799488 date "2021-06-01" @default.
• W3144799488 modified "2023-10-07" @default.
• W3144799488 title "Formulation and in vivo study of the solid effervescent system as a new strategy for oral glutamine delivery" @default.
• W3144799488 cites W1192338606 @default.
• W3144799488 cites W1511260511 @default.
• W3144799488 cites W1912556536 @default.
• W3144799488 cites W1967975794 @default.
• W3144799488 cites W1975136353 @default.
• W3144799488 cites W1976674183 @default.
• W3144799488 cites W1989061685 @default.
• W3144799488 cites W1998865909 @default.
• W3144799488 cites W1999533443 @default.
• W3144799488 cites W2002562802 @default.
• W3144799488 cites W2002908188 @default.
• W3144799488 cites W2005357958 @default.
• W3144799488 cites W2008479890 @default.
• W3144799488 cites W2012268383 @default.
• W3144799488 cites W2013193811 @default.
• W3144799488 cites W2014561863 @default.
• W3144799488 cites W2014782282 @default.
• W3144799488 cites W2046811018 @default.
• W3144799488 cites W2048076920 @default.
• W3144799488 cites W2055444002 @default.
• W3144799488 cites W2059280852 @default.
• W3144799488 cites W2061009763 @default.
• W3144799488 cites W2096422707 @default.
• W3144799488 cites W2116162955 @default.
• W3144799488 cites W2133061394 @default.
• W3144799488 cites W2139318998 @default.
• W3144799488 cites W2140248316 @default.
• W3144799488 cites W2141566507 @default.
• W3144799488 cites W2141856080 @default.
• W3144799488 cites W2149906371 @default.
• W3144799488 cites W2152871789 @default.
• W3144799488 cites W2164129135 @default.
• W3144799488 cites W2194152592 @default.
• W3144799488 cites W2271070564 @default.
• W3144799488 cites W2344038980 @default.
• W3144799488 cites W2468932732 @default.
• W3144799488 cites W2557353581 @default.
• W3144799488 cites W2609032890 @default.
• W3144799488 cites W2618317496 @default.
• W3144799488 cites W2740895060 @default.
• W3144799488 cites W2769443894 @default.
• W3144799488 cites W2808748074 @default.
• W3144799488 cites W2884899172 @default.
• W3144799488 cites W2897213700 @default.
• W3144799488 cites W2901848941 @default.
• W3144799488 cites W2981662425 @default.
• W3144799488 cites W3336349 @default.
• W3144799488 cites W4235063132 @default.
• W3144799488 cites W4243459759 @default.
• W3144799488 doi "https://doi.org/10.1016/j.jddst.2021.102516" @default.
• W3144799488 hasPublicationYear "2021" @default.
• W3144799488 type Work @default.
• W3144799488 sameAs 3144799488 @default.
• W3144799488 citedByCount "3" @default.
• W3144799488 countsByYear W31447994882022 @default.
• W3144799488 countsByYear W31447994882023 @default.
• W3144799488 crossrefType "journal-article" @default.
• W3144799488 hasAuthorship W3144799488A5003626587 @default.
• W3144799488 hasAuthorship W3144799488A5024261209 @default.
• W3144799488 hasAuthorship W3144799488A5050525574 @default.
• W3144799488 hasAuthorship W3144799488A5052090694 @default.
• W3144799488 hasAuthorship W3144799488A5052115473 @default.
• W3144799488 hasAuthorship W3144799488A5070576555 @default.
• W3144799488 hasAuthorship W3144799488A5083882147 @default.
• W3144799488 hasConcept C13965031 @default.
• W3144799488 hasConcept C155574463 @default.
• W3144799488 hasConcept C178790620 @default.
• W3144799488 hasConcept C181389837 @default.
• W3144799488 hasConcept C185592680 @default.
• W3144799488 hasConcept C2779349466 @default.
• W3144799488 hasConcept C43617362 @default.
• W3144799488 hasConcept C515207424 @default.
• W3144799488 hasConcept C55493867 @default.
• W3144799488 hasConcept C71924100 @default.
• W3144799488 hasConcept C98274493 @default.
• W3144799488 hasConceptScore W3144799488C13965031 @default.
• W3144799488 hasConceptScore W3144799488C155574463 @default.
• W3144799488 hasConceptScore W3144799488C178790620 @default.
• W3144799488 hasConceptScore W3144799488C181389837 @default.
• W3144799488 hasConceptScore W3144799488C185592680 @default.
• W3144799488 hasConceptScore W3144799488C2779349466 @default.
• W3144799488 hasConceptScore W3144799488C43617362 @default.
• W3144799488 hasConceptScore W3144799488C515207424 @default.
• W3144799488 hasConceptScore W3144799488C55493867 @default.
• W3144799488 hasConceptScore W3144799488C71924100 @default.
• W3144799488 hasConceptScore W3144799488C98274493 @default.

• next