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• W3144820203 abstract "Owing to neurite promoting, antioxidant and anti-inflammatory effects of Euxanthone (Eux), the investigation was aimed to probe the neuroprotective efficacy of Eux against traumatic spinal cord injury (t-SCI) in rats and whether Eux can improve neuropathic function in t-SCI.Sprague-Dawley (SD) rats were randomized in - Sham, t-SCI, Eux30, and Eux60 (t-SCI + 30 and 60 mg/kg respectively). Animals with compression force-induced t-SCI were subjected to estimation of locomotor functions. Spinal cord water content and Evans blue (EB) effusion were determined for quantifying edema and intactness of the spinal cord. Oxidative stress and immunochemical markers were quantified by ELISA and western blotting.Findings revealed that Eux60 group animals had greater Basso, Beattie, and Bresnahan (BBB) and (incline plane test) IPT score indicating improved locomotor functions. There was a reduction in the spinal edema and water content after Eux treatment, together with lowering of oxidative stress markers. The expression of IL-6, IL-12, IL-1β, caspase-3, RANKL, TLR4, NF-κB, p-38, PI3K, and Akt in spinal cord tissues of t-SCI-induced rats was lowered after Eux treatment.Overall, the investigation advocates that Eux attenuates t-SCI and associated inflammation, oxidative damage, and resulting apoptosis via modulation of TLR4/NF-κB/p38 and PI3K/Akt signaling cascade." @default.
• W3144820203 created "2021-04-13" @default.
• W3144820203 creator A5013958390 @default.
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• W3144820203 creator A5080733133 @default.
• W3144820203 date "2021-01-01" @default.
• W3144820203 modified "2023-10-17" @default.
• W3144820203 title "Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model" @default.
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• W3144820203 doi "https://doi.org/10.1515/tnsci-2021-0012" @default.
• W3144820203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7969821" @default.
• W3144820203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33777443" @default.
• W3144820203 hasPublicationYear "2021" @default.
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