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- W3144828497 abstract "Objective To investigate the role of CD4~+CD25~+ regulatory T cells(Tr cells) in the pathogenesis of asthma in children.Methods Peripheral blood samples were collected from 20 pediatric patients with asthma,10 male and 10 female,aged 7(3-12),and 20 healthy children,10 male and 10 female,aged 6.5(2-11).Lymphocytes were isolated.Flow cytometry was used to examine the percentages of CD4~+CD25~+ regulatory T cells,IL-10 secreting CD4~+CD25~+ regulatory T cells(CD4~+CD25~+-IL-10),and transforming growth factor(TGF)-β secreting CD4~+CD25~+ regulatory T cells(CD4~+CD25~+-TGF-β).RT-PCR and real-time PCR were used to detect the mRNA expression of suppressor of cytokine signal 1(SOSC1) and Foxp3.Results The percentages of CD4~+CD25~+ regulatory T cells of the asthma children was 6.51%±1.94%,significantly lower than that of the healthy children(11.96%±2.30%,P0.01);the percentage of CD4~+CD25~+-IL-10 of the asthma children was 1.46%±0.35%,significantly lower than that of the healthy children(5.65%±1.70%,P0.01);and the percentage of CD4~+CD25~+-TGF-β of the asthma children was 1.24%±0.21%,significantly lower than that t of the healthy children(4.23%±1.65%,P0.01).The Foxp3 mRNA expression of the asthma children was 0.12±0.05,significantly lower than that of the healthy children(1.71±0.58,P0.01);and the SOCS1 mRNA expression of the asthma children was 0.38±0.19,significantly lower than that of the healthy children(1.51±0.41,P0.01).Conclusion The decrease of CD4~+CD25~+ regulatory T cells may be involved in the pathogenesis of asthma.The decreased mRNA expression of Foxp3 and SOCS1 may be associated with the aberrant development of CD4~+CD25~+ regulatory T cells." @default.
- W3144828497 created "2021-04-13" @default.
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- W3144828497 date "2006-01-01" @default.
- W3144828497 modified "2023-09-28" @default.
- W3144828497 title "The role of CD4~+ CD25~+ regulatory T cells in the pathogenesis of asthma in children" @default.
- W3144828497 hasPublicationYear "2006" @default.
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