Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144828512> ?p ?o ?g. }
- W3144828512 endingPage "346" @default.
- W3144828512 startingPage "338" @default.
- W3144828512 abstract "Down syndrome (DS) is caused by trisomy 21 (Ts21) and results in skeletal deficits including shortened stature, low bone mineral density, and a predisposition to early onset osteoporosis. Ts21 causes significant alterations in skeletal development, morphology of the appendicular skeleton, bone homeostasis, age-related bone loss, and bone strength. However, the genetic or cellular origins of DS skeletal phenotypes remain unclear. New studies reveal a sexual dimorphism in characteristics and onset of skeletal deficits that differ between DS and typically developing individuals. Age-related bone loss occurs earlier in the DS as compared to general population. Perturbations of DS skeletal quality arise from alterations in cellular and molecular pathways affected by the overexpression of trisomic genes. Sex-specific alterations occur in critical developmental pathways that disrupt bone accrual, remodeling, and homeostasis and are compounded by aging, resulting in increased risks for osteopenia, osteoporosis, and fracture in individuals with DS." @default.
- W3144828512 created "2021-04-13" @default.
- W3144828512 creator A5001180699 @default.
- W3144828512 creator A5003296446 @default.
- W3144828512 date "2021-04-08" @default.
- W3144828512 modified "2023-10-01" @default.
- W3144828512 title "Current Analysis of Skeletal Phenotypes in Down Syndrome" @default.
- W3144828512 cites W1481537913 @default.
- W3144828512 cites W1493924061 @default.
- W3144828512 cites W1517371674 @default.
- W3144828512 cites W1751673191 @default.
- W3144828512 cites W1967943295 @default.
- W3144828512 cites W1972044192 @default.
- W3144828512 cites W1982451886 @default.
- W3144828512 cites W1987252938 @default.
- W3144828512 cites W1989907220 @default.
- W3144828512 cites W1996066732 @default.
- W3144828512 cites W1997381668 @default.
- W3144828512 cites W2000353984 @default.
- W3144828512 cites W2007800603 @default.
- W3144828512 cites W2014157276 @default.
- W3144828512 cites W2015658471 @default.
- W3144828512 cites W2021943331 @default.
- W3144828512 cites W2023370651 @default.
- W3144828512 cites W2025280409 @default.
- W3144828512 cites W2030811514 @default.
- W3144828512 cites W2034700718 @default.
- W3144828512 cites W2038769797 @default.
- W3144828512 cites W2040049468 @default.
- W3144828512 cites W2040440197 @default.
- W3144828512 cites W2042916026 @default.
- W3144828512 cites W2044935263 @default.
- W3144828512 cites W2059617293 @default.
- W3144828512 cites W2060241396 @default.
- W3144828512 cites W2069389312 @default.
- W3144828512 cites W2069926335 @default.
- W3144828512 cites W2075544506 @default.
- W3144828512 cites W2079860207 @default.
- W3144828512 cites W2084233122 @default.
- W3144828512 cites W2092247599 @default.
- W3144828512 cites W2096452264 @default.
- W3144828512 cites W2100061591 @default.
- W3144828512 cites W2101705652 @default.
- W3144828512 cites W2102940020 @default.
- W3144828512 cites W2107341459 @default.
- W3144828512 cites W2112930007 @default.
- W3144828512 cites W2116247013 @default.
- W3144828512 cites W2117152239 @default.
- W3144828512 cites W2117684960 @default.
- W3144828512 cites W2129004191 @default.
- W3144828512 cites W2129736783 @default.
- W3144828512 cites W2133278365 @default.
- W3144828512 cites W2156666342 @default.
- W3144828512 cites W2157858898 @default.
- W3144828512 cites W2161348707 @default.
- W3144828512 cites W2168140313 @default.
- W3144828512 cites W2223832541 @default.
- W3144828512 cites W2247836688 @default.
- W3144828512 cites W2293284325 @default.
- W3144828512 cites W2340088736 @default.
- W3144828512 cites W2347208728 @default.
- W3144828512 cites W2460810002 @default.
- W3144828512 cites W2468259612 @default.
- W3144828512 cites W2507240154 @default.
- W3144828512 cites W2513722645 @default.
- W3144828512 cites W2556362401 @default.
- W3144828512 cites W2618870391 @default.
- W3144828512 cites W2727340347 @default.
- W3144828512 cites W2736131271 @default.
- W3144828512 cites W2754247140 @default.
- W3144828512 cites W2754534244 @default.
- W3144828512 cites W2757874772 @default.
- W3144828512 cites W2761369644 @default.
- W3144828512 cites W2762704480 @default.
- W3144828512 cites W2770132031 @default.
- W3144828512 cites W2770273625 @default.
- W3144828512 cites W2790176262 @default.
- W3144828512 cites W2893888806 @default.
- W3144828512 cites W2918167618 @default.
- W3144828512 cites W2943939551 @default.
- W3144828512 cites W2945018458 @default.
- W3144828512 cites W2971489145 @default.
- W3144828512 cites W2978792437 @default.
- W3144828512 cites W2998617730 @default.
- W3144828512 cites W3016275894 @default.
- W3144828512 cites W340627938 @default.
- W3144828512 cites W4210691315 @default.
- W3144828512 cites W4243723058 @default.
- W3144828512 cites W4245408774 @default.
- W3144828512 doi "https://doi.org/10.1007/s11914-021-00674-y" @default.
- W3144828512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8316313" @default.
- W3144828512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33830429" @default.
- W3144828512 hasPublicationYear "2021" @default.
- W3144828512 type Work @default.
- W3144828512 sameAs 3144828512 @default.
- W3144828512 citedByCount "9" @default.
- W3144828512 countsByYear W31448285122022 @default.
- W3144828512 countsByYear W31448285122023 @default.