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- W3144840675 abstract "瞄准：在老鼠观察距骨 complanatus flavonoids (ACF ) 的反肝纤维变性效果。方法：在老鼠的肝纤维变性模型被 interperitoneally 注射 0.2 mL/100 g 建立 0.5% dimethylnitrosamine，三次一个星期。同时，老鼠是管理 ACF (30， 60， 120 mg/kg ) 或用番红花作原料而制成的植物盐基(0.1 mg/kg ) 一次为 1 瞬间的一天。类型的浆液 N-propeptide 我职业人员骨胶原(PINP ) 和类型 III 职业人员骨胶原(PIIINP ) 用 ELISA 被测量。Malondialdehyde (MDA ) 和在肝的织物的超级氧化物歧化酶(草皮) 被评估。矩阵金属 protease-1 (MMP-1 ) mRNA 表示是由 RT-PCR 的 assayed，金属 protease-1 (TIMP-1 ) 的织物禁止者的蛋白质表示被免疫组织化学分析。结果：在 ACF 组，草皮活动增加了， MDA 内容与肝纤维变性模型组相比减少了。在 ACF-2 和 -3 组的浆液 PINP 和 PIIINP 内容在模型组与那些相比减少了。在 ACF-2 和 -3 组，显著地增加的 MMP-1 mRNA 的表示和 TIMP-1 的蛋白质表示在模型组与那相比减少了。结论：ACF 的 antifibrotic 机制每氧化和骨胶原合成和降级与它对类脂化合物的影响被联系。" @default.
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- W3144840675 date "2005-01-01" @default.
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- W3144840675 title "Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats" @default.
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