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- W3144843302 abstract "To investigate the morphology and capacity of bone marrow colony forming unity - fibroblast (CFUF) from APBSCT patients before anti ＇after pretreatment. 21 case peripheral blood stem cell transplantation (PBSCT) patients were treated with pretreatment. The changes of morphology of the bone marrow stromal ceils were assayed by light micro,scope and electron microscope, respectively. The numbers of CFU - F were assayed by Dexter type. The bone marrow stromal cells occured different types of morphology from PBSCT patients treated with chemotherapy or chemotherapy- TBI pretreatment, respectively, compared with controls. The transmission electron microscope showed that the endoplasmic reticula was dilated, the matrix of mitochondria appeared pale and the cristae of mitochondria became shorter in stromal cells from chemotherapy-TBI patients compared with those of controls. The structure of mitochondria from combined chemotherapy-TBI pretreatment appeared severe degeneration and disorder. The numbers of CFU - F from combined radiation - chemotherapy injury, were significantly decreased compared with that before pretreatment and the chemotherapy injury (P<0.01), respectively. The change of cell morphology and capacity of CFU-F for bone marrow stromal cells is one of impairment injury mechanism of bone marrow hematopoietic inductive microenvironment from PBSCT patients post pretreatment." @default.
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- W3144843302 date "2005-01-01" @default.
- W3144843302 modified "2023-09-27" @default.
- W3144843302 title "Morphology and growth capacity of bone marrow stromal cells in vitro from APBSCT patients post pretreatment" @default.
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