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• W3144857708 abstract "The association between polymorphism of DNA methyltransferases 3B and cancer risk has been widely studied recently, and no consensus conclusion is available up to now. We perform a comprehensive search using the databases of Medline, ISI Web of Knowledge and Embase. The odds ratio (OR) and its 95% confidence interval (95% CI) are used to investigate the strength of the association. A total of 24 case-control studies with 15,647 individuals are included in this meta-analysis. For -149C ( T (17 studies, 5229 cases and 6910 controls), no evidence indicate that individuals carrying the variant genotypes (CC ? CT), relative to those carrying the wild homozygote TT genotype, have an increased risk of cancer (OR = 1.03; 95% CI = 0.84-1.26; P = 0.76). Similarly, no cancer risk is found in the subgroup analyses. For -579G ( T (11 studies, 3513 cases and 3714 controls), significantly decreased risks of cancer are observed, and the ORs (95% CI) are 0.70 (0.56-0.87) for GT versus TT, 0.70 (0.57-0.85) for GG ? GT versus TT and 0.76 (0.63-0.93) for G-allele versus T-allele, respectively. Subgroup analy- ses stratified by ethnicity and types of cancer are also per- formed, and results indicated that -579G ( C poly- morphism is associated with risk of cancer in Asians (0.68 (0.53-0.87) for GT vs. TT) but not in Europeans (0.82 (0.63-1.07) for GT vs. TT). We also observe that the -579G is associated with decreased risk of colorectal cancer (0.49(0.38-0.62) for GT vs. TT). More studies with larger sample size were needed to provide more precise evidence." @default.
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• W3144857708 date "2012-01-01" @default.
• W3144857708 modified "2023-09-26" @default.
• W3144857708 title "DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies" @default.
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