FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144868517> ?p ?o ?g. }

• W3144868517 endingPage "111480" @default.
• W3144868517 startingPage "111480" @default.
• W3144868517 abstract "Osteogenesis and angiogenesis acts as an essential role in repairing large tibial defects (LTDs). Total flavonoids of rhizoma drynariae (TFRD), a traditional Chinese medicinal herb, is reported to show anabolic effects on fracture healing. However, whether TFRD could improve the bone formation and angiogenesis in LTDs remains unknown. The purpose of this study was to evaluate the effect of TFRD on bone formation and angiogenesis in LTDs in distraction osteogenesis (DO). Using a previously established fracture model, LTD rats was established with circular external fixator (CEF). All rats then randomly divided into TFRD low dosage group (with DO), TFRD medium dosage group (with DO), TFRD high dosage group (with DO), model group (with DO) and blank group (without DO). Twelve weeks after treatment, according to X-ray and Micro-CT, TFRD groups (especially in medium dosage group) can significantly promote the formation of a large number of epiphyses and improve new bone mineralization compared with model group, and the results of HE and Masson staining and in vitro ALP level of BMSC also demonstrated the formation of bone matrix and mineralization in the TFRD groups. Also, angiographic imaging suggested that total flavonoids of TFRD was able to promote angiogenesis in the defect area. Consistently, TFRD significantly increased the levels of BMP-2, SMAD1, SMAD4, RUNX-2, OSX and VEGF in LTD rats based on ELISA and Real-Time PCR. In addition, we found that ALP activity of TFRD medium dosage group reached a peak after 10 days of induction through BMSC cell culture in vitro experiment. TFRD promoted bone formation in LTD through activation of BMP-Smad signaling pathway, which provides a promising new strategy for repairing bone defects in DO surgeries." @default.
• W3144868517 created "2021-04-13" @default.
• W3144868517 creator A5020906285 @default.
• W3144868517 creator A5022213926 @default.
• W3144868517 creator A5025528013 @default.
• W3144868517 creator A5026194818 @default.
• W3144868517 creator A5026612608 @default.
• W3144868517 creator A5027534235 @default.
• W3144868517 creator A5035163413 @default.
• W3144868517 creator A5047369788 @default.
• W3144868517 creator A5047444631 @default.
• W3144868517 creator A5073014859 @default.
• W3144868517 creator A5077758547 @default.
• W3144868517 creator A5086664284 @default.
• W3144868517 creator A5089051425 @default.
• W3144868517 date "2021-06-01" @default.
• W3144868517 modified "2023-10-16" @default.
• W3144868517 title "Total flavonoids of rhizoma drynariae ameliorates bone formation and mineralization in BMP-Smad signaling pathway induced large tibial defect rats" @default.
• W3144868517 cites W1532393868 @default.
• W3144868517 cites W1964302588 @default.
• W3144868517 cites W1976718809 @default.
• W3144868517 cites W1976729236 @default.
• W3144868517 cites W1976739921 @default.
• W3144868517 cites W1977022422 @default.
• W3144868517 cites W1987113787 @default.
• W3144868517 cites W1999522281 @default.
• W3144868517 cites W2020343457 @default.
• W3144868517 cites W2039149547 @default.
• W3144868517 cites W2042886692 @default.
• W3144868517 cites W2050362176 @default.
• W3144868517 cites W2061343594 @default.
• W3144868517 cites W2068389936 @default.
• W3144868517 cites W2079814657 @default.
• W3144868517 cites W2088885492 @default.
• W3144868517 cites W2092821344 @default.
• W3144868517 cites W2100840830 @default.
• W3144868517 cites W2103031848 @default.
• W3144868517 cites W2110485236 @default.
• W3144868517 cites W2127967460 @default.
• W3144868517 cites W2129309301 @default.
• W3144868517 cites W2139561611 @default.
• W3144868517 cites W2145483033 @default.
• W3144868517 cites W2227295794 @default.
• W3144868517 cites W2258294989 @default.
• W3144868517 cites W2343938601 @default.
• W3144868517 cites W2507544731 @default.
• W3144868517 cites W2609697243 @default.
• W3144868517 cites W2621124186 @default.
• W3144868517 cites W2709758240 @default.
• W3144868517 cites W2731250871 @default.
• W3144868517 cites W2743044098 @default.
• W3144868517 cites W2898932705 @default.
• W3144868517 cites W2921009060 @default.
• W3144868517 cites W3016093640 @default.
• W3144868517 doi "https://doi.org/10.1016/j.biopha.2021.111480" @default.
• W3144868517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33774316" @default.
• W3144868517 hasPublicationYear "2021" @default.
• W3144868517 type Work @default.
• W3144868517 sameAs 3144868517 @default.
• W3144868517 citedByCount "18" @default.
• W3144868517 countsByYear W31448685172021 @default.
• W3144868517 countsByYear W31448685172022 @default.
• W3144868517 countsByYear W31448685172023 @default.
• W3144868517 crossrefType "journal-article" @default.
• W3144868517 hasAuthorship W3144868517A5020906285 @default.
• W3144868517 hasAuthorship W3144868517A5022213926 @default.
• W3144868517 hasAuthorship W3144868517A5025528013 @default.
• W3144868517 hasAuthorship W3144868517A5026194818 @default.
• W3144868517 hasAuthorship W3144868517A5026612608 @default.
• W3144868517 hasAuthorship W3144868517A5027534235 @default.
• W3144868517 hasAuthorship W3144868517A5035163413 @default.
• W3144868517 hasAuthorship W3144868517A5047369788 @default.
• W3144868517 hasAuthorship W3144868517A5047444631 @default.
• W3144868517 hasAuthorship W3144868517A5073014859 @default.
• W3144868517 hasAuthorship W3144868517A5077758547 @default.
• W3144868517 hasAuthorship W3144868517A5086664284 @default.
• W3144868517 hasAuthorship W3144868517A5089051425 @default.
• W3144868517 hasBestOaLocation W31448685171 @default.
• W3144868517 hasConcept C1008401 @default.
• W3144868517 hasConcept C105702510 @default.
• W3144868517 hasConcept C111696902 @default.
• W3144868517 hasConcept C126322002 @default.
• W3144868517 hasConcept C178790620 @default.
• W3144868517 hasConcept C185592680 @default.
• W3144868517 hasConcept C2780394083 @default.
• W3144868517 hasConcept C2993291840 @default.
• W3144868517 hasConcept C537208039 @default.
• W3144868517 hasConcept C71924100 @default.
• W3144868517 hasConcept C8337478 @default.
• W3144868517 hasConceptScore W3144868517C1008401 @default.
• W3144868517 hasConceptScore W3144868517C105702510 @default.
• W3144868517 hasConceptScore W3144868517C111696902 @default.
• W3144868517 hasConceptScore W3144868517C126322002 @default.
• W3144868517 hasConceptScore W3144868517C178790620 @default.
• W3144868517 hasConceptScore W3144868517C185592680 @default.
• W3144868517 hasConceptScore W3144868517C2780394083 @default.
• W3144868517 hasConceptScore W3144868517C2993291840 @default.
• W3144868517 hasConceptScore W3144868517C537208039 @default.

• next