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- W3144869385 abstract "导致骨胶原的关节炎(中央情报局) 是一个动物模型，它非常在致病和病理类似于人的风湿性关节炎(RA ) 。证据建议 T 淋巴细胞或他们的功能的抑制能减轻关节炎的前进。那么 arthritogenic T 房间受体(TCR ) 的管理编码病原的 TCR V 可变区域的可变区域肽或 DNA 疫苗可以为对自体免疫的疾病设计特定的免疫疗法提供有用信息。热吃惊蛋白质(HSP ) 有提起 antigenic immunogenicity 和 HSP70 的功能对关节炎有保护的效果。我们以前在中央情报局老鼠的关节表明了病原的占优势的 T 房间受体 V5.2 和 V8.2 clonotypes 的存在。在这研究，我们构造了 recombinant 真核细胞的表示向量 pTARGET-TCR V5.2/8.2-HSP70，并且在中央情报局老鼠上评估了他们的保护的效果。保护的效果被注射这些 recombinant DNA 在中央情报局老鼠观察疫苗，能减轻关节炎索引，减少在浆液的 IFN-C 和古怪抗体的层次，和增加 IL-4 的层次。病理学的变化不象在控制中央情报局老鼠观察的那些一样严肃。与二支联合疫苗注射的老鼠比与单个疫苗管理的中央情报局老鼠显示出更好保护的效果。这些结果证明 recombinant DNA 疫苗 pTARGET-TCR V5.2-HSP70 和 pTARGET-TCR V8.2-HSP70 能显著地减轻中央情报局老鼠的关节炎的症状，并且如果这二支疫苗在联合被使用，更好保护的效果能被完成。" @default.
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- W3144869385 date "2007-01-01" @default.
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- W3144869385 title "Protective Effects of Overexpression TCR Vβ5.2-HSP70 and TCR Vβ8.2-HSP70 against Collagen-Induced Arthritis in Rats" @default.
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