Matches in SemOpenAlex for { <https://semopenalex.org/work/W3144953192> ?p ?o ?g. }
- W3144953192 abstract "The cladoceran crustacean Daphnia has long been a model of energy allocation studies due to its important position in the trophic cascade of freshwater ecosystems. However, the loci for controlling energy allocation between life history traits still remain unknown. Here, we report CRISPR/Cas-mediated target mutagenesis of DNA methyltransferase 3.1 (DNMT3.1) that is upregulated in response to caloric restriction in Daphnia magna. The resulting biallelic mutant is viable and did not show any change in growth rate, reproduction, and longevity under nutrient rich conditions. In contrast, under starved conditions, the growth rate of this DNMT3.1 mutant was increased but its reproduction was reciprocally reduced compared to the wild type when the growth and reproduction activities competed during a period from instar 4 to 8. The life span of this mutant was significantly shorter than that of the wild type. We also compared transcriptomes between DNMT3.1 mutant and wild type under nutrient-rich and starved conditions. Consistent with the DNMT3.1 mutant phenotypes, the starved condition led to changes in the transcriptomes of the mutant including differential expression of vitellogenin genes. In addition, we found upregulation of the I am not dead yet (INDY) ortholog, which has been known to shorten the life span in Drosophila, explaining the shorter life span of the DNMT3.1 mutant. These results establish DNMT3.1 as a key regulator for life span and energy allocation between growth and reproduction during caloric restriction. Our findings reveal how energy allocation is implemented by selective expression of a DNMT3 ortholog that is widely distributed among animals. We also infer a previously unidentified adaptation of Daphnia that invests more energy for reproduction than growth under starved conditions." @default.
- W3144953192 created "2021-04-13" @default.
- W3144953192 creator A5005879454 @default.
- W3144953192 creator A5041139506 @default.
- W3144953192 creator A5074624931 @default.
- W3144953192 creator A5088410956 @default.
- W3144953192 date "2021-04-01" @default.
- W3144953192 modified "2023-10-15" @default.
- W3144953192 title "DNMT3.1 controls trade-offs between growth, reproduction, and life span under starved conditions in Daphnia magna" @default.
- W3144953192 cites W1507359070 @default.
- W3144953192 cites W1570622790 @default.
- W3144953192 cites W1573270171 @default.
- W3144953192 cites W1586316126 @default.
- W3144953192 cites W1750498507 @default.
- W3144953192 cites W1966506799 @default.
- W3144953192 cites W1972705715 @default.
- W3144953192 cites W1977463456 @default.
- W3144953192 cites W1981286603 @default.
- W3144953192 cites W1986569125 @default.
- W3144953192 cites W1987749377 @default.
- W3144953192 cites W1989622653 @default.
- W3144953192 cites W1990276200 @default.
- W3144953192 cites W1993246714 @default.
- W3144953192 cites W1994811904 @default.
- W3144953192 cites W1995959637 @default.
- W3144953192 cites W2000046950 @default.
- W3144953192 cites W2001338440 @default.
- W3144953192 cites W2004296421 @default.
- W3144953192 cites W2022261962 @default.
- W3144953192 cites W2024848067 @default.
- W3144953192 cites W2031046866 @default.
- W3144953192 cites W2036354783 @default.
- W3144953192 cites W2047617138 @default.
- W3144953192 cites W2057140490 @default.
- W3144953192 cites W2060446375 @default.
- W3144953192 cites W2061946349 @default.
- W3144953192 cites W2070265688 @default.
- W3144953192 cites W2070704344 @default.
- W3144953192 cites W2072003932 @default.
- W3144953192 cites W2075429508 @default.
- W3144953192 cites W2077659966 @default.
- W3144953192 cites W2080771607 @default.
- W3144953192 cites W2082118089 @default.
- W3144953192 cites W2089325551 @default.
- W3144953192 cites W2089417246 @default.
- W3144953192 cites W2096260958 @default.
- W3144953192 cites W2096391240 @default.
- W3144953192 cites W2097144268 @default.
- W3144953192 cites W2114894226 @default.
- W3144953192 cites W2114970231 @default.
- W3144953192 cites W2115621041 @default.
- W3144953192 cites W2119776584 @default.
- W3144953192 cites W2124049725 @default.
- W3144953192 cites W2124483853 @default.
- W3144953192 cites W2124933556 @default.
- W3144953192 cites W2146927794 @default.
- W3144953192 cites W2154975687 @default.
- W3144953192 cites W2186164471 @default.
- W3144953192 cites W2208721939 @default.
- W3144953192 cites W2322715144 @default.
- W3144953192 cites W2366212322 @default.
- W3144953192 cites W2596255045 @default.
- W3144953192 cites W2754430206 @default.
- W3144953192 cites W2766534177 @default.
- W3144953192 cites W2903808414 @default.
- W3144953192 cites W2912453742 @default.
- W3144953192 cites W2921380850 @default.
- W3144953192 cites W2953162895 @default.
- W3144953192 cites W2972896653 @default.
- W3144953192 cites W2976747241 @default.
- W3144953192 cites W2977156123 @default.
- W3144953192 cites W2999893067 @default.
- W3144953192 cites W3101718907 @default.
- W3144953192 cites W3112849708 @default.
- W3144953192 cites W4229520201 @default.
- W3144953192 cites W4232424030 @default.
- W3144953192 cites W4235147472 @default.
- W3144953192 cites W4254687493 @default.
- W3144953192 cites W47781189 @default.
- W3144953192 cites W62553678 @default.
- W3144953192 doi "https://doi.org/10.1038/s41598-021-86578-4" @default.
- W3144953192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8016896" @default.
- W3144953192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33795753" @default.
- W3144953192 hasPublicationYear "2021" @default.
- W3144953192 type Work @default.
- W3144953192 sameAs 3144953192 @default.
- W3144953192 citedByCount "3" @default.
- W3144953192 countsByYear W31449531922022 @default.
- W3144953192 crossrefType "journal-article" @default.
- W3144953192 hasAuthorship W3144953192A5005879454 @default.
- W3144953192 hasAuthorship W3144953192A5041139506 @default.
- W3144953192 hasAuthorship W3144953192A5074624931 @default.
- W3144953192 hasAuthorship W3144953192A5088410956 @default.
- W3144953192 hasBestOaLocation W31449531921 @default.
- W3144953192 hasConcept C104317684 @default.
- W3144953192 hasConcept C143065580 @default.
- W3144953192 hasConcept C178790620 @default.
- W3144953192 hasConcept C185592680 @default.
- W3144953192 hasConcept C207583985 @default.
- W3144953192 hasConcept C2780158794 @default.